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Multiple endocrine neoplasia type 1 (MEN1) in two Asian families.
Hum Genet. 1994 Nov; 94(5):468-72.HG

Abstract

Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disease characterized by neoplasia of the parathyroid glands, anterior pituitary and endocrine pancreas, is rarely reported in Asian populations. The MEN1 gene, mapped to chromosome 11q13 but yet to be cloned, has been found to be homogeneous in Caucasian populations through linkage analysis. Here, two previously unreported Asian kindreds with MEN1 are described; linkage analysis using microsatellite polymorphic markers in the MEN1 region was carried out. The first kindred, of Mongolian-Chinese origin, is a multigeneration family with over 150 living members, eight of whom are affected to date. The second kindred is of Chinese origin consisting of four affected members. Linkage to chromosome 11q13 was confirmed in both kindreds, supporting evidence for genetic homogeneity. A recombination in the larger kindred localizes the gene distal to marker D11S956, consistent with its placement from previous studies. We also show that it is feasible to use these markers for predictive testing, as four gene carriers were detected in 13 family members with unknown disease status in the first kindred.

Authors+Show Affiliations

Department of Diabetes and Endocrinology, Princess Alexandra Hospital. Woolloongabba, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7959678

Citation

Teh, B T., et al. "Multiple Endocrine Neoplasia Type 1 (MEN1) in Two Asian Families." Human Genetics, vol. 94, no. 5, 1994, pp. 468-72.
Teh BT, Hii SI, David R, et al. Multiple endocrine neoplasia type 1 (MEN1) in two Asian families. Hum Genet. 1994;94(5):468-72.
Teh, B. T., Hii, S. I., David, R., Parameswaran, V., Grimmond, S., Walters, M. K., Tan, T. T., Nancarrow, D. J., Chan, S. P., & Mennon, J. (1994). Multiple endocrine neoplasia type 1 (MEN1) in two Asian families. Human Genetics, 94(5), 468-72.
Teh BT, et al. Multiple Endocrine Neoplasia Type 1 (MEN1) in Two Asian Families. Hum Genet. 1994;94(5):468-72. PubMed PMID: 7959678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple endocrine neoplasia type 1 (MEN1) in two Asian families. A1 - Teh,B T, AU - Hii,S I, AU - David,R, AU - Parameswaran,V, AU - Grimmond,S, AU - Walters,M K, AU - Tan,T T, AU - Nancarrow,D J, AU - Chan,S P, AU - Mennon,J, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 468 EP - 72 JF - Human genetics JO - Hum Genet VL - 94 IS - 5 N2 - Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disease characterized by neoplasia of the parathyroid glands, anterior pituitary and endocrine pancreas, is rarely reported in Asian populations. The MEN1 gene, mapped to chromosome 11q13 but yet to be cloned, has been found to be homogeneous in Caucasian populations through linkage analysis. Here, two previously unreported Asian kindreds with MEN1 are described; linkage analysis using microsatellite polymorphic markers in the MEN1 region was carried out. The first kindred, of Mongolian-Chinese origin, is a multigeneration family with over 150 living members, eight of whom are affected to date. The second kindred is of Chinese origin consisting of four affected members. Linkage to chromosome 11q13 was confirmed in both kindreds, supporting evidence for genetic homogeneity. A recombination in the larger kindred localizes the gene distal to marker D11S956, consistent with its placement from previous studies. We also show that it is feasible to use these markers for predictive testing, as four gene carriers were detected in 13 family members with unknown disease status in the first kindred. SN - 0340-6717 UR - https://www.unboundmedicine.com/medline/citation/7959678/Multiple_endocrine_neoplasia_type_1__MEN1__in_two_Asian_families_ L2 - http://www.diseaseinfosearch.org/result/4954 DB - PRIME DP - Unbound Medicine ER -