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Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens.
Immunology. 1994 Jul; 82(3):365-9.I

Abstract

Autoimmune prostatitis developed spontaneously in (C57BL/6N x A/J)F1 (B6A) mice, when thymectomy (Tx) was conducted on day 3 after birth (Tx-3). The lesion could be prevented by a single injection of CD4+ spleen cells (4 x 10(6)) from normal males, but not from normal females or newborn orchidectomized (Orx-0) mice. However, when spleen cells were obtained from Orx-0 mice that had received a dihydrotestosterone (DHT) pellet when adult to develop a mature prostate, prostatitis could be prevented, suggesting that immune tolerance to prostate antigen(s) is maintained by a CD4+ tissue-specific suppressor T cell (Ts) population(s), which is activated by a specific autoantigen(s) in the mature prostate. The result that even CD4+ cells from Orx-0 mice that were thymectomized as adults and treated thereafter with DHT were effective for prevention of prostatitis suggests that activation of this Ts population takes place in the peripheral lymphoid organs, and that it maintains peripheral tolerance to autoantigen in the prostate of these mice and probably also in normal mice.

Authors+Show Affiliations

Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7959869

Citation

Taguchi, O, et al. "Tissue-specific Suppressor T Cells Involved in Self-tolerance Are Activated Extrathymically By Self-antigens." Immunology, vol. 82, no. 3, 1994, pp. 365-9.
Taguchi O, Kontani K, Ikeda H, et al. Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens. Immunology. 1994;82(3):365-9.
Taguchi, O., Kontani, K., Ikeda, H., Kezuka, T., Takeuchi, M., Takahashi, T., & Takahashi, T. (1994). Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens. Immunology, 82(3), 365-9.
Taguchi O, et al. Tissue-specific Suppressor T Cells Involved in Self-tolerance Are Activated Extrathymically By Self-antigens. Immunology. 1994;82(3):365-9. PubMed PMID: 7959869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens. AU - Taguchi,O, AU - Kontani,K, AU - Ikeda,H, AU - Kezuka,T, AU - Takeuchi,M, AU - Takahashi,T, AU - Takahashi,T, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 365 EP - 9 JF - Immunology JO - Immunology VL - 82 IS - 3 N2 - Autoimmune prostatitis developed spontaneously in (C57BL/6N x A/J)F1 (B6A) mice, when thymectomy (Tx) was conducted on day 3 after birth (Tx-3). The lesion could be prevented by a single injection of CD4+ spleen cells (4 x 10(6)) from normal males, but not from normal females or newborn orchidectomized (Orx-0) mice. However, when spleen cells were obtained from Orx-0 mice that had received a dihydrotestosterone (DHT) pellet when adult to develop a mature prostate, prostatitis could be prevented, suggesting that immune tolerance to prostate antigen(s) is maintained by a CD4+ tissue-specific suppressor T cell (Ts) population(s), which is activated by a specific autoantigen(s) in the mature prostate. The result that even CD4+ cells from Orx-0 mice that were thymectomized as adults and treated thereafter with DHT were effective for prevention of prostatitis suggests that activation of this Ts population takes place in the peripheral lymphoid organs, and that it maintains peripheral tolerance to autoantigen in the prostate of these mice and probably also in normal mice. SN - 0019-2805 UR - https://www.unboundmedicine.com/medline/citation/7959869/Tissue_specific_suppressor_T_cells_involved_in_self_tolerance_are_activated_extrathymically_by_self_antigens_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7959869/ DB - PRIME DP - Unbound Medicine ER -