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Effect of pentagastrin on gastric bicarbonate secretion in patients with duodenal ulcer & healthy controls.
Indian J Med Res. 1994 Sep; 100:122-6.IJ

Abstract

We studied the gastric acid and bicarbonate secretion rates in 12 patients with duodenal ulcer and 6 age matched healthy controls. Measurements of gastric juice volume (nonparietal and parietal), acidity and osmolality were done. The ulcer patients secreted more acid, parietal and nonparietal fluid than controls under basal conditions and after subcutaneous pentagastrin injection (6 micrograms/kg body weight). However, the gastric bicarbonate secretion was similar in the duodenal ulcer patients and controls, both under basal state as well as after pentagastrin stimulation. The gastric acidity was similar in ulcer patients and control subjects under both the states (49.3 +2- 4.5 vs 50.0 +/- 6.0 mmol/l basally, 85.2 +/- 8.9 vs 63.4 +/- 6.6 mmol/l after pentagastrin injection respectively). Thus, gastric bicarbonate secretion was similar, whereas parietal and nonparietal volume secretions were increased in patients with duodenal ulcer as compared to controls.

Authors+Show Affiliations

Department of Gastroenterology, Postgraduate Institute of Medical Education & Research, Chandigarh.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

7959968

Citation

Singh, K, et al. "Effect of Pentagastrin On Gastric Bicarbonate Secretion in Patients With Duodenal Ulcer & Healthy Controls." The Indian Journal of Medical Research, vol. 100, 1994, pp. 122-6.
Singh K, Nain CK, Singh V, et al. Effect of pentagastrin on gastric bicarbonate secretion in patients with duodenal ulcer & healthy controls. Indian J Med Res. 1994;100:122-6.
Singh, K., Nain, C. K., Singh, V., Thapa, B. R., & Ganguly, N. K. (1994). Effect of pentagastrin on gastric bicarbonate secretion in patients with duodenal ulcer & healthy controls. The Indian Journal of Medical Research, 100, 122-6.
Singh K, et al. Effect of Pentagastrin On Gastric Bicarbonate Secretion in Patients With Duodenal Ulcer & Healthy Controls. Indian J Med Res. 1994;100:122-6. PubMed PMID: 7959968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of pentagastrin on gastric bicarbonate secretion in patients with duodenal ulcer & healthy controls. AU - Singh,K, AU - Nain,C K, AU - Singh,V, AU - Thapa,B R, AU - Ganguly,N K, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 122 EP - 6 JF - The Indian journal of medical research JO - Indian J Med Res VL - 100 N2 - We studied the gastric acid and bicarbonate secretion rates in 12 patients with duodenal ulcer and 6 age matched healthy controls. Measurements of gastric juice volume (nonparietal and parietal), acidity and osmolality were done. The ulcer patients secreted more acid, parietal and nonparietal fluid than controls under basal conditions and after subcutaneous pentagastrin injection (6 micrograms/kg body weight). However, the gastric bicarbonate secretion was similar in the duodenal ulcer patients and controls, both under basal state as well as after pentagastrin stimulation. The gastric acidity was similar in ulcer patients and control subjects under both the states (49.3 +2- 4.5 vs 50.0 +/- 6.0 mmol/l basally, 85.2 +/- 8.9 vs 63.4 +/- 6.6 mmol/l after pentagastrin injection respectively). Thus, gastric bicarbonate secretion was similar, whereas parietal and nonparietal volume secretions were increased in patients with duodenal ulcer as compared to controls. SN - 0971-5916 UR - https://www.unboundmedicine.com/medline/citation/7959968/Effect_of_pentagastrin_on_gastric_bicarbonate_secretion_in_patients_with_duodenal_ulcer_&_healthy_controls_ DB - PRIME DP - Unbound Medicine ER -