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Treatment of a recurrent keratoacanthoma with oral isotretinoin.
Int J Dermatol. 1994 Aug; 33(8):579-83.IJ

Abstract

BACKGROUND

Keratoacanthoma is a benign epithelial tumor that occurs on the sun-exposed skin of elderly people. Development of KAS on functionally and cosmetically important areas such as the face poses the therapeutic challenge to minimize functional and cosmetic damage. Oral isotretinoin (Accutane, Roche Laboratories) has been reported to be an effective treatment of multiple as well as solitary keratoacanthomas.

CASE REPORT

A 45-year-old man with a large keratoacanthoma on the nasal ala, recurrent after surgical excision, was treated with 1 mg/kg/day (80 mg/day) oral isotretinoin (Accutane). Cessation of tumor progression was evident within 1 week after initiation of therapy, and tumor regression was evident within 2 weeks. Tumor size diminished rapidly over the ensuing weeks and complete resolution at 12 weeks was confirmed by biopsy.

CONCLUSION

An initial trial of oral isotretinoin is an alternative to immediate surgical excision for the treatment of large keratoacanthomas in instances when tumor removal would cause considerable cosmetic deformity.

Authors+Show Affiliations

Department of Dermatology, Baylor College of Medicine, Houston, Texas.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

7960358

Citation

Wong, W Y., et al. "Treatment of a Recurrent Keratoacanthoma With Oral Isotretinoin." International Journal of Dermatology, vol. 33, no. 8, 1994, pp. 579-83.
Wong WY, Kolbusz RV, Goldberg LH, et al. Treatment of a recurrent keratoacanthoma with oral isotretinoin. Int J Dermatol. 1994;33(8):579-83.
Wong, W. Y., Kolbusz, R. V., Goldberg, L. H., & Guana, A. (1994). Treatment of a recurrent keratoacanthoma with oral isotretinoin. International Journal of Dermatology, 33(8), 579-83.
Wong WY, et al. Treatment of a Recurrent Keratoacanthoma With Oral Isotretinoin. Int J Dermatol. 1994;33(8):579-83. PubMed PMID: 7960358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of a recurrent keratoacanthoma with oral isotretinoin. AU - Wong,W Y, AU - Kolbusz,R V, AU - Goldberg,L H, AU - Guana,A, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 579 EP - 83 JF - International journal of dermatology JO - Int J Dermatol VL - 33 IS - 8 N2 - BACKGROUND: Keratoacanthoma is a benign epithelial tumor that occurs on the sun-exposed skin of elderly people. Development of KAS on functionally and cosmetically important areas such as the face poses the therapeutic challenge to minimize functional and cosmetic damage. Oral isotretinoin (Accutane, Roche Laboratories) has been reported to be an effective treatment of multiple as well as solitary keratoacanthomas. CASE REPORT: A 45-year-old man with a large keratoacanthoma on the nasal ala, recurrent after surgical excision, was treated with 1 mg/kg/day (80 mg/day) oral isotretinoin (Accutane). Cessation of tumor progression was evident within 1 week after initiation of therapy, and tumor regression was evident within 2 weeks. Tumor size diminished rapidly over the ensuing weeks and complete resolution at 12 weeks was confirmed by biopsy. CONCLUSION: An initial trial of oral isotretinoin is an alternative to immediate surgical excision for the treatment of large keratoacanthomas in instances when tumor removal would cause considerable cosmetic deformity. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/7960358/Treatment_of_a_recurrent_keratoacanthoma_with_oral_isotretinoin_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0011-9059&date=1994&volume=33&issue=8&spage=579 DB - PRIME DP - Unbound Medicine ER -