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Motor and mental side effects of clozapine.
J Clin Psychiatry. 1994 Sep; 55 Suppl B:107-9.JC

Abstract

Long-term experience with clozapine has shown that the agent has a motor and mental side effect profile that is distinct in many ways from classical neuroleptics. It can produce a parkinsonian-like bradykinesia and mild akathisia, but no rigidity and rarely tremor. In patients with tardive dyskinesia induced by other neuroleptics, clozapine permits the dyskinesia to disappear in about half the cases. That clozapine may induce tardive dyskinesia in extremely rare cases cannot be excluded, but it seems more likely that this tardive dyskinesia in clozapine-treated patients is due to previous treatment with classical neuroleptics. The earlier clozapine is started, the less chance for development of tardive dyskinesia. As do other neuroleptics, clozapine can elicit sedation and asthenia, but corresponding to the motoric extrapyramidal syndrome, clozapine causes emotional indifference ("mental parkinsonism"), depression, and restlessness to a significantly lesser degree, which may be of importance in the higher compliance seen with this drug.

Authors+Show Affiliations

St. Hans Hospital, Roskilde, Denmark.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7961551

Citation

Gerlach, J, and L Peacock. "Motor and Mental Side Effects of Clozapine." The Journal of Clinical Psychiatry, vol. 55 Suppl B, 1994, pp. 107-9.
Gerlach J, Peacock L. Motor and mental side effects of clozapine. J Clin Psychiatry. 1994;55 Suppl B:107-9.
Gerlach, J., & Peacock, L. (1994). Motor and mental side effects of clozapine. The Journal of Clinical Psychiatry, 55 Suppl B, 107-9.
Gerlach J, Peacock L. Motor and Mental Side Effects of Clozapine. J Clin Psychiatry. 1994;55 Suppl B:107-9. PubMed PMID: 7961551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor and mental side effects of clozapine. AU - Gerlach,J, AU - Peacock,L, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 107 EP - 9 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 55 Suppl B N2 - Long-term experience with clozapine has shown that the agent has a motor and mental side effect profile that is distinct in many ways from classical neuroleptics. It can produce a parkinsonian-like bradykinesia and mild akathisia, but no rigidity and rarely tremor. In patients with tardive dyskinesia induced by other neuroleptics, clozapine permits the dyskinesia to disappear in about half the cases. That clozapine may induce tardive dyskinesia in extremely rare cases cannot be excluded, but it seems more likely that this tardive dyskinesia in clozapine-treated patients is due to previous treatment with classical neuroleptics. The earlier clozapine is started, the less chance for development of tardive dyskinesia. As do other neuroleptics, clozapine can elicit sedation and asthenia, but corresponding to the motoric extrapyramidal syndrome, clozapine causes emotional indifference ("mental parkinsonism"), depression, and restlessness to a significantly lesser degree, which may be of importance in the higher compliance seen with this drug. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/7961551/Motor_and_mental_side_effects_of_clozapine_ L2 - https://medlineplus.gov/schizophrenia.html DB - PRIME DP - Unbound Medicine ER -