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Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism.
J Clin Endocrinol Metab. 1994 Oct; 79(4):1115-21.JC

Abstract

Hyperactivity of 5 alpha-reductase in the skin is considered a major mechanism of excessive hair growth in hirsute women with normal levels of serum androgens (idiopathic hirsutism). Preventing the conversion of testosterone to dihydrotestosterone by inhibiting 5 alpha-reductase activity could thus be the most rational and effective treatment in this condition. The present study evaluated the effects of the oral administration of finasteride (5 mg once daily) for 6 months in 17 young women with idiopathic hirsutism, 5 of whom were also given an oral contraceptive. The degree of hirsutism (graded by a modified Ferriman-Gallwey score), serum sex hormone levels, and serum and urinary 5 alpha-metabolism steroid profiles were determined basally and periodically during the treatment period. The modified Ferriman-Gallwey score showed a remarkable reduction after 6 months of finasteride treatment (5.9 +/- 0.6 vs. 11.7 +/- 1.3; P < 0.01). Serum 5 alpha-dihydrotestosterone and 3 alpha-androstanediol glucuronide levels were decreased, and urinary C19 and C21 5 beta/5 alpha metabolite ratios were increased compared with pretreatment values. No significant adverse effect was reported. In women treated with finasteride and oral contraceptive, clinical efficacy was slightly more pronounced. In conclusion, the 5 alpha-reductase inhibitor finasteride is well tolerated and seems to be a useful tool in the treatment of idiopathic hirsutism.

Authors+Show Affiliations

Moghetti P
Division of Metabolic Diseases, University of Verona, Italy.
Castello R
No affiliation info available
Magnani CM
No affiliation info available
Tosi F
No affiliation info available
Negri C
No affiliation info available
Armanini D
No affiliation info available
Bellotti G
No affiliation info available
Muggeo M
No affiliation info available

MeSH

AdultAndrogensCholestenone 5 alpha-ReductaseContraceptives, OralDrug Therapy, CombinationFemaleFinasterideHirsutismHormonesHumansLuteinizing HormoneOxidoreductases

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7962284

Citation

Moghetti, P, et al. "Clinical and Hormonal Effects of the 5 Alpha-reductase Inhibitor Finasteride in Idiopathic Hirsutism." The Journal of Clinical Endocrinology and Metabolism, vol. 79, no. 4, 1994, pp. 1115-21.
Moghetti P, Castello R, Magnani CM, et al. Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism. J Clin Endocrinol Metab. 1994;79(4):1115-21.
Moghetti, P., Castello, R., Magnani, C. M., Tosi, F., Negri, C., Armanini, D., Bellotti, G., & Muggeo, M. (1994). Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism. The Journal of Clinical Endocrinology and Metabolism, 79(4), 1115-21.
Moghetti P, et al. Clinical and Hormonal Effects of the 5 Alpha-reductase Inhibitor Finasteride in Idiopathic Hirsutism. J Clin Endocrinol Metab. 1994;79(4):1115-21. PubMed PMID: 7962284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism. AU - Moghetti,P, AU - Castello,R, AU - Magnani,C M, AU - Tosi,F, AU - Negri,C, AU - Armanini,D, AU - Bellotti,G, AU - Muggeo,M, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 1115 EP - 21 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 79 IS - 4 N2 - Hyperactivity of 5 alpha-reductase in the skin is considered a major mechanism of excessive hair growth in hirsute women with normal levels of serum androgens (idiopathic hirsutism). Preventing the conversion of testosterone to dihydrotestosterone by inhibiting 5 alpha-reductase activity could thus be the most rational and effective treatment in this condition. The present study evaluated the effects of the oral administration of finasteride (5 mg once daily) for 6 months in 17 young women with idiopathic hirsutism, 5 of whom were also given an oral contraceptive. The degree of hirsutism (graded by a modified Ferriman-Gallwey score), serum sex hormone levels, and serum and urinary 5 alpha-metabolism steroid profiles were determined basally and periodically during the treatment period. The modified Ferriman-Gallwey score showed a remarkable reduction after 6 months of finasteride treatment (5.9 +/- 0.6 vs. 11.7 +/- 1.3; P < 0.01). Serum 5 alpha-dihydrotestosterone and 3 alpha-androstanediol glucuronide levels were decreased, and urinary C19 and C21 5 beta/5 alpha metabolite ratios were increased compared with pretreatment values. No significant adverse effect was reported. In women treated with finasteride and oral contraceptive, clinical efficacy was slightly more pronounced. In conclusion, the 5 alpha-reductase inhibitor finasteride is well tolerated and seems to be a useful tool in the treatment of idiopathic hirsutism. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/7962284/Clinical_and_hormonal_effects_of_the_5_alpha_reductase_inhibitor_finasteride_in_idiopathic_hirsutism_ DB - PRIME DP - Unbound Medicine ER -