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Decreased cardiac baroreflex sensitivity is not due to cardiac hypertrophy in NG-nitro-L-arginine methyl ester-induced hypertension.
J Hypertens. 1994 Jul; 12(7):791-5.JH

Abstract

OBJECTIVE

To investigate the link between cardiac hypertrophy, elevated blood pressure level and baroreflex impairment, we assessed cardiac baroreflex function in a hypertensive model almost devoid of cardiac hypertrophy, obtained by nitric oxide synthesis inhibition.

METHODS

Thirteen adult male Wistar rats were treated orally with NG-nitro-L-arginine methyl ester (L-NAME, 50 mg/kg per 24 h) for 4 weeks. Fifteen control rats received tap water. At the end of the treatment aortic blood pressure was recorded continuously and the baroreceptor-heart rate curve was assessed by bolus injections of phenylephrine and sodium nitroprusside (10 different doses of each).

RESULTS

Mean blood pressure was higher in L-NAME rats than in control rats, whereas body weight was similar. Total heart weight and left ventricular weight did not differ between the groups. Cardiac baroreflex was reset in hypertensive rats, as indicated by a rightwards shift of the mean blood pressure-heart rate curve. Its gain was decreased significantly in L-NAME rats, whereas the heart rate range was not different between the two groups.

CONCLUSION

L-NAME hypertensive rats exhibit an original impairment of cardiac baroreflex, characterized by a range-independent decreased gain which is not due to cardiac hypertrophy.

Authors+Show Affiliations

Department of Physiology and Clinical Pharmacology, URA CNRS 1483, Faculty of Pharmacy, Lyon, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7963507

Citation

Lantelme, P, et al. "Decreased Cardiac Baroreflex Sensitivity Is Not Due to Cardiac Hypertrophy in NG-nitro-L-arginine Methyl Ester-induced Hypertension." Journal of Hypertension, vol. 12, no. 7, 1994, pp. 791-5.
Lantelme P, Lo M, Sassard J. Decreased cardiac baroreflex sensitivity is not due to cardiac hypertrophy in NG-nitro-L-arginine methyl ester-induced hypertension. J Hypertens. 1994;12(7):791-5.
Lantelme, P., Lo, M., & Sassard, J. (1994). Decreased cardiac baroreflex sensitivity is not due to cardiac hypertrophy in NG-nitro-L-arginine methyl ester-induced hypertension. Journal of Hypertension, 12(7), 791-5.
Lantelme P, Lo M, Sassard J. Decreased Cardiac Baroreflex Sensitivity Is Not Due to Cardiac Hypertrophy in NG-nitro-L-arginine Methyl Ester-induced Hypertension. J Hypertens. 1994;12(7):791-5. PubMed PMID: 7963507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased cardiac baroreflex sensitivity is not due to cardiac hypertrophy in NG-nitro-L-arginine methyl ester-induced hypertension. AU - Lantelme,P, AU - Lo,M, AU - Sassard,J, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 791 EP - 5 JF - Journal of hypertension JO - J Hypertens VL - 12 IS - 7 N2 - OBJECTIVE: To investigate the link between cardiac hypertrophy, elevated blood pressure level and baroreflex impairment, we assessed cardiac baroreflex function in a hypertensive model almost devoid of cardiac hypertrophy, obtained by nitric oxide synthesis inhibition. METHODS: Thirteen adult male Wistar rats were treated orally with NG-nitro-L-arginine methyl ester (L-NAME, 50 mg/kg per 24 h) for 4 weeks. Fifteen control rats received tap water. At the end of the treatment aortic blood pressure was recorded continuously and the baroreceptor-heart rate curve was assessed by bolus injections of phenylephrine and sodium nitroprusside (10 different doses of each). RESULTS: Mean blood pressure was higher in L-NAME rats than in control rats, whereas body weight was similar. Total heart weight and left ventricular weight did not differ between the groups. Cardiac baroreflex was reset in hypertensive rats, as indicated by a rightwards shift of the mean blood pressure-heart rate curve. Its gain was decreased significantly in L-NAME rats, whereas the heart rate range was not different between the two groups. CONCLUSION: L-NAME hypertensive rats exhibit an original impairment of cardiac baroreflex, characterized by a range-independent decreased gain which is not due to cardiac hypertrophy. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/7963507/Decreased_cardiac_baroreflex_sensitivity_is_not_due_to_cardiac_hypertrophy_in_NG_nitro_L_arginine_methyl_ester_induced_hypertension_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7963507.ui DB - PRIME DP - Unbound Medicine ER -