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Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin.
Nature. 1994 Nov 10; 372(6502):190-3.Nat

Abstract

In contrast to sessile cell types, lymphocytes migrate through the vasculature to become diffusely distributed in tissues or organized in lymphoid structures. A complex array of adhesion molecules including selectins, integrins and their counter-receptors mediate lymphocyte homing and migration into tissues and may be constitutively expressed or induced. However, the molecules that mediate the tissue-specific retention of lymphocytes within the parenchyma have not been identified. Along the epithelium at the basolateral surface of enterocytes, intestinal intraepithelial lymphocytes are found. These T cells of the mucosal immune system serve as a model for the tissue-specific compartmentalization of lymphocytes. We investigated whether the localization of these intestinal intraepithelial lymphocytes could be mediated by specific interactions between adhesion molecules expressed selectively on this subpopulation of T cells and tissue-restricted adhesion molecules on epithelial cells. Here we show that heterotypic adhesive interactions between epithelial cells and intraepithelial lymphocytes in vitro are mediated by E-cadherin and the alpha E beta 7 integrin.

Authors+Show Affiliations

Department of Rheumatology and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7969453

Citation

Cepek, K L., et al. "Adhesion Between Epithelial Cells and T Lymphocytes Mediated By E-cadherin and the Alpha E Beta 7 Integrin." Nature, vol. 372, no. 6502, 1994, pp. 190-3.
Cepek KL, Shaw SK, Parker CM, et al. Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature. 1994;372(6502):190-3.
Cepek, K. L., Shaw, S. K., Parker, C. M., Russell, G. J., Morrow, J. S., Rimm, D. L., & Brenner, M. B. (1994). Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature, 372(6502), 190-3.
Cepek KL, et al. Adhesion Between Epithelial Cells and T Lymphocytes Mediated By E-cadherin and the Alpha E Beta 7 Integrin. Nature. 1994 Nov 10;372(6502):190-3. PubMed PMID: 7969453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. AU - Cepek,K L, AU - Shaw,S K, AU - Parker,C M, AU - Russell,G J, AU - Morrow,J S, AU - Rimm,D L, AU - Brenner,M B, PY - 1994/11/10/pubmed PY - 1994/11/10/medline PY - 1994/11/10/entrez SP - 190 EP - 3 JF - Nature JO - Nature VL - 372 IS - 6502 N2 - In contrast to sessile cell types, lymphocytes migrate through the vasculature to become diffusely distributed in tissues or organized in lymphoid structures. A complex array of adhesion molecules including selectins, integrins and their counter-receptors mediate lymphocyte homing and migration into tissues and may be constitutively expressed or induced. However, the molecules that mediate the tissue-specific retention of lymphocytes within the parenchyma have not been identified. Along the epithelium at the basolateral surface of enterocytes, intestinal intraepithelial lymphocytes are found. These T cells of the mucosal immune system serve as a model for the tissue-specific compartmentalization of lymphocytes. We investigated whether the localization of these intestinal intraepithelial lymphocytes could be mediated by specific interactions between adhesion molecules expressed selectively on this subpopulation of T cells and tissue-restricted adhesion molecules on epithelial cells. Here we show that heterotypic adhesive interactions between epithelial cells and intraepithelial lymphocytes in vitro are mediated by E-cadherin and the alpha E beta 7 integrin. SN - 0028-0836 UR - https://www.unboundmedicine.com/medline/citation/7969453/Adhesion_between_epithelial_cells_and_T_lymphocytes_mediated_by_E_cadherin_and_the_alpha_E_beta_7_integrin_ DB - PRIME DP - Unbound Medicine ER -