Tags

Type your tag names separated by a space and hit enter

Summary of combined clinical analysis of controlled clinical trials with tizanidine.
Neurology. 1994 Nov; 44(11 Suppl 9):S60-8; discussion S68-9.Neur

Abstract

Data from three placebo-controlled and 11 active-controlled studies of tizanidine were combined to permit analysis of the subsets, which were too small to evaluate within the individual studies. Overall analysis of placebo-controlled data confirms the effectiveness of tizanidine in reducing muscle tone in patients with spasticity of spinal cord origin. Subset analyses suggest that patients with more severe spasticity are more likely to respond, but age, sex, and race were not predictive of response. Comparisons of tizanidine with active controls showed no differences in efficacy compared with baclofen or diazepam. However, when compared with controls, patients treated with tizanidine did not experience increased weakness. Furthermore, patients tolerated tizanidine better than the control medications. More patients experienced adverse events during tizanidine treatment than did patients receiving placebo. The most common adverse events reported were dry mouth, somnolence, asthenia, and dizziness. Mild elevations in liver function tests were noted occasionally, but improved in all patients with dose reduction or withdrawal. Three patients from the double-blind database reported formed visual hallucinations. All three cleared; two continued tizanidine, and one discontinued.

Authors+Show Affiliations

Clinical/Regulatory Affairs, Athena Neurosciences, Inc., South San Francisco, California.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

7970013

Citation

Wallace, J D.. "Summary of Combined Clinical Analysis of Controlled Clinical Trials With Tizanidine." Neurology, vol. 44, no. 11 Suppl 9, 1994, pp. S60-8; discussion S68-9.
Wallace JD. Summary of combined clinical analysis of controlled clinical trials with tizanidine. Neurology. 1994;44(11 Suppl 9):S60-8; discussion S68-9.
Wallace, J. D. (1994). Summary of combined clinical analysis of controlled clinical trials with tizanidine. Neurology, 44(11 Suppl 9), S60-8; discussion S68-9.
Wallace JD. Summary of Combined Clinical Analysis of Controlled Clinical Trials With Tizanidine. Neurology. 1994;44(11 Suppl 9):S60-8; discussion S68-9. PubMed PMID: 7970013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Summary of combined clinical analysis of controlled clinical trials with tizanidine. A1 - Wallace,J D, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - S60-8; discussion S68-9 JF - Neurology JO - Neurology VL - 44 IS - 11 Suppl 9 N2 - Data from three placebo-controlled and 11 active-controlled studies of tizanidine were combined to permit analysis of the subsets, which were too small to evaluate within the individual studies. Overall analysis of placebo-controlled data confirms the effectiveness of tizanidine in reducing muscle tone in patients with spasticity of spinal cord origin. Subset analyses suggest that patients with more severe spasticity are more likely to respond, but age, sex, and race were not predictive of response. Comparisons of tizanidine with active controls showed no differences in efficacy compared with baclofen or diazepam. However, when compared with controls, patients treated with tizanidine did not experience increased weakness. Furthermore, patients tolerated tizanidine better than the control medications. More patients experienced adverse events during tizanidine treatment than did patients receiving placebo. The most common adverse events reported were dry mouth, somnolence, asthenia, and dizziness. Mild elevations in liver function tests were noted occasionally, but improved in all patients with dose reduction or withdrawal. Three patients from the double-blind database reported formed visual hallucinations. All three cleared; two continued tizanidine, and one discontinued. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/7970013/Summary_of_combined_clinical_analysis_of_controlled_clinical_trials_with_tizanidine_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7970013.ui DB - PRIME DP - Unbound Medicine ER -