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[Sulfadiazine nephrolithiasis and nephropathy].
Schweiz Med Wochenschr. 1994 Nov 19; 124(46):2100-5.SM

Abstract

Sulfadiazine-nephropathy and -nephrolithiasis were well known complications of high dose sulfadiazine therapy 50 years ago. In the last few years high dose sulfadiazine therapy has been widely used for treatment of toxoplasmic encephalitis in AIDS patients. As a consequence sulfadiazine-nephropathy and -nephrolithiasis have become increasingly common. We describe 2 patients with the typical picture of these complications. Therapy is based on the fact that the solubility of sulfadiazine and its acetylated metabolite are markedly improved at higher urine-pH levels. Urine alkalinization is also effective for prophylaxis during sulfadiazine treatment. We present our guidelines for prophylaxis and treatment of these complications.

Authors+Show Affiliations

Medizinische Universitätspoliklinik, Inselspital Bern.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

7973549

Citation

Furrer, H, et al. "[Sulfadiazine Nephrolithiasis and Nephropathy]." Schweizerische Medizinische Wochenschrift, vol. 124, no. 46, 1994, pp. 2100-5.
Furrer H, von Overbeck J, Jaeger P, et al. [Sulfadiazine nephrolithiasis and nephropathy]. Schweiz Med Wochenschr. 1994;124(46):2100-5.
Furrer, H., von Overbeck, J., Jaeger, P., & Hess, B. (1994). [Sulfadiazine nephrolithiasis and nephropathy]. Schweizerische Medizinische Wochenschrift, 124(46), 2100-5.
Furrer H, et al. [Sulfadiazine Nephrolithiasis and Nephropathy]. Schweiz Med Wochenschr. 1994 Nov 19;124(46):2100-5. PubMed PMID: 7973549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Sulfadiazine nephrolithiasis and nephropathy]. AU - Furrer,H, AU - von Overbeck,J, AU - Jaeger,P, AU - Hess,B, PY - 1994/11/19/pubmed PY - 1994/11/19/medline PY - 1994/11/19/entrez SP - 2100 EP - 5 JF - Schweizerische medizinische Wochenschrift JO - Schweiz Med Wochenschr VL - 124 IS - 46 N2 - Sulfadiazine-nephropathy and -nephrolithiasis were well known complications of high dose sulfadiazine therapy 50 years ago. In the last few years high dose sulfadiazine therapy has been widely used for treatment of toxoplasmic encephalitis in AIDS patients. As a consequence sulfadiazine-nephropathy and -nephrolithiasis have become increasingly common. We describe 2 patients with the typical picture of these complications. Therapy is based on the fact that the solubility of sulfadiazine and its acetylated metabolite are markedly improved at higher urine-pH levels. Urine alkalinization is also effective for prophylaxis during sulfadiazine treatment. We present our guidelines for prophylaxis and treatment of these complications. SN - 0036-7672 UR - https://www.unboundmedicine.com/medline/citation/7973549/[Sulfadiazine_nephrolithiasis_and_nephropathy]_ L2 - https://medlineplus.gov/hivaids.html DB - PRIME DP - Unbound Medicine ER -