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Large pituitary adenoma of the sphenoid sinus and the nasopharynx: report of a case with ultrastructural evaluations.
Surg Neurol. 1994 Oct; 42(4):330-4.SN

Abstract

A unique case of nonfunctioning pituitary adenoma exclusively involving the sphenoid sinus and the nasopharynx is reported. The computed tomography and magnetic resonance imaging (MRI) clearly depicted the presence of a large, soft mass in the sphenoid sinus and its extensive invasion to the sphenoid wing and the clivus. In particular MRI was found useful in delineating precise anatomic relationships between this sphenoid sinus tumor and the pituitary fossa. The sphenoid sinus tumor was partially resected by sublabial transnasal approach, and the intact dura mater of the base of the pituitary fossa was confirmed. Pathologic examinations including immunocytochemical and ultrastructural studies showed that the tumor was classified as a nonfunctioning acidophilic pituitary adenoma. Despite the endocrine-inactive tumor, the presence of small secretory granules in the cytoplasm demonstrated by electron microscopic studies was of significant importance in establishing the diagnosis. This rare tumor is reviewed in the literature in the context of nasopharyngeal extension of pituitary adenomas, and a possibility of ectopic occurrence and growth is also discussed in the presented case.

Authors+Show Affiliations

Department of Laboratory of Medicine, Akita University Medical Center, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

7974131

Citation

Kikuchi, K, et al. "Large Pituitary Adenoma of the Sphenoid Sinus and the Nasopharynx: Report of a Case With Ultrastructural Evaluations." Surgical Neurology, vol. 42, no. 4, 1994, pp. 330-4.
Kikuchi K, Kowada M, Sasaki J, et al. Large pituitary adenoma of the sphenoid sinus and the nasopharynx: report of a case with ultrastructural evaluations. Surg Neurol. 1994;42(4):330-4.
Kikuchi, K., Kowada, M., Sasaki, J., & Sageshima, M. (1994). Large pituitary adenoma of the sphenoid sinus and the nasopharynx: report of a case with ultrastructural evaluations. Surgical Neurology, 42(4), 330-4.
Kikuchi K, et al. Large Pituitary Adenoma of the Sphenoid Sinus and the Nasopharynx: Report of a Case With Ultrastructural Evaluations. Surg Neurol. 1994;42(4):330-4. PubMed PMID: 7974131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Large pituitary adenoma of the sphenoid sinus and the nasopharynx: report of a case with ultrastructural evaluations. AU - Kikuchi,K, AU - Kowada,M, AU - Sasaki,J, AU - Sageshima,M, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 330 EP - 4 JF - Surgical neurology JO - Surg Neurol VL - 42 IS - 4 N2 - A unique case of nonfunctioning pituitary adenoma exclusively involving the sphenoid sinus and the nasopharynx is reported. The computed tomography and magnetic resonance imaging (MRI) clearly depicted the presence of a large, soft mass in the sphenoid sinus and its extensive invasion to the sphenoid wing and the clivus. In particular MRI was found useful in delineating precise anatomic relationships between this sphenoid sinus tumor and the pituitary fossa. The sphenoid sinus tumor was partially resected by sublabial transnasal approach, and the intact dura mater of the base of the pituitary fossa was confirmed. Pathologic examinations including immunocytochemical and ultrastructural studies showed that the tumor was classified as a nonfunctioning acidophilic pituitary adenoma. Despite the endocrine-inactive tumor, the presence of small secretory granules in the cytoplasm demonstrated by electron microscopic studies was of significant importance in establishing the diagnosis. This rare tumor is reviewed in the literature in the context of nasopharyngeal extension of pituitary adenomas, and a possibility of ectopic occurrence and growth is also discussed in the presented case. SN - 0090-3019 UR - https://www.unboundmedicine.com/medline/citation/7974131/Large_pituitary_adenoma_of_the_sphenoid_sinus_and_the_nasopharynx:_report_of_a_case_with_ultrastructural_evaluations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0090-3019(94)90404-9 DB - PRIME DP - Unbound Medicine ER -