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Relationship of tissue factor pathway inhibitor activity to plasma lipoproteins and myocardial infarction at a young age.
Thromb Haemost. 1994 Jun; 71(6):707-12.TH

Abstract

Tissue factor pathway inhibitor (TFPI) activity was quantified in two cohorts of young male post-infarction patients and in population-based control subjects to explore the relationships between TFPI activity and plasma lipoproteins and to address the issue of coordinate regulation of factor VII and TFPI in hyperlipidaemia and premature coronary heart disease (CHD). Participants were investigated in the fasting state and after an oral fat load. Basal TFPI activity and factor VII antigen (VIIag) levels were found to be increased in the patients (TFPI activity 1.25 +/- 0.23 vs 1.17 +/- 0.20 U/ml, p < 0.05; VIIag 537.7 +/- 127.7 vs 479.4 +/- 93.4 ng/ml, p < 0.001). The parallel increase was accounted for by patients with hypertriglyceridaemic lipoprotein phenotypes. In contrast, the level of activated factor VII (VIIa) neither differed significantly between patients and controls, nor between patients with different lipoprotein phenotypes. The elevated TFPI activity in the patients was closely associated with the plasma level of dense low density lipoprotein (LDL) particles (r = 0.46, p < 0.001) and with the plasma concentration of the small, dense high density lipoprotein (HDL) subspecies HDL3b (r = 0.34, p < 0.01).

Authors+Show Affiliations

Division of Cardiology, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7974336

Citation

Moor, E, et al. "Relationship of Tissue Factor Pathway Inhibitor Activity to Plasma Lipoproteins and Myocardial Infarction at a Young Age." Thrombosis and Haemostasis, vol. 71, no. 6, 1994, pp. 707-12.
Moor E, Hamsten A, Karpe F, et al. Relationship of tissue factor pathway inhibitor activity to plasma lipoproteins and myocardial infarction at a young age. Thromb Haemost. 1994;71(6):707-12.
Moor, E., Hamsten, A., Karpe, F., Båvenholm, P., Blombäck, M., & Silveira, A. (1994). Relationship of tissue factor pathway inhibitor activity to plasma lipoproteins and myocardial infarction at a young age. Thrombosis and Haemostasis, 71(6), 707-12.
Moor E, et al. Relationship of Tissue Factor Pathway Inhibitor Activity to Plasma Lipoproteins and Myocardial Infarction at a Young Age. Thromb Haemost. 1994;71(6):707-12. PubMed PMID: 7974336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of tissue factor pathway inhibitor activity to plasma lipoproteins and myocardial infarction at a young age. AU - Moor,E, AU - Hamsten,A, AU - Karpe,F, AU - Båvenholm,P, AU - Blombäck,M, AU - Silveira,A, PY - 1994/6/1/pubmed PY - 1994/6/1/medline PY - 1994/6/1/entrez SP - 707 EP - 12 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 71 IS - 6 N2 - Tissue factor pathway inhibitor (TFPI) activity was quantified in two cohorts of young male post-infarction patients and in population-based control subjects to explore the relationships between TFPI activity and plasma lipoproteins and to address the issue of coordinate regulation of factor VII and TFPI in hyperlipidaemia and premature coronary heart disease (CHD). Participants were investigated in the fasting state and after an oral fat load. Basal TFPI activity and factor VII antigen (VIIag) levels were found to be increased in the patients (TFPI activity 1.25 +/- 0.23 vs 1.17 +/- 0.20 U/ml, p < 0.05; VIIag 537.7 +/- 127.7 vs 479.4 +/- 93.4 ng/ml, p < 0.001). The parallel increase was accounted for by patients with hypertriglyceridaemic lipoprotein phenotypes. In contrast, the level of activated factor VII (VIIa) neither differed significantly between patients and controls, nor between patients with different lipoprotein phenotypes. The elevated TFPI activity in the patients was closely associated with the plasma level of dense low density lipoprotein (LDL) particles (r = 0.46, p < 0.001) and with the plasma concentration of the small, dense high density lipoprotein (HDL) subspecies HDL3b (r = 0.34, p < 0.01). SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/7974336/Relationship_of_tissue_factor_pathway_inhibitor_activity_to_plasma_lipoproteins_and_myocardial_infarction_at_a_young_age_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -