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What is hereditary nonpolyposis colorectal cancer (HNPCC).
Anticancer Res. 1994 Jul-Aug; 14(4B):1613-5.AR

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominantly inherited disease associated with a marked increase in cancer susceptibility, especially cancer of the colorectum. It is one of the most common cancer predisposing syndromes affecting as many as one in 400 individuals in the Western World. Two (mismatch repair) genes (hMSH2 on chromosome 2p and hMLH1 on chromosome 3p) have recently been identified which appear to be involved in the development of cancer in most of the HNPCC families. Colorectal cancer in HNPCC differs from sporadic colorectal cancer by an early age of onset, a proclivity for the proximal colon, and an excess of synchronous and metachronous colorectal cancers. A variety of extracolonic tumors may be encountered in HNPCC, including cancers of the endometrium, stomach, small bowel, urinary tract (renal pelvis and ureter), biliary system and ovary. The diagnosis HNPCC is currently based upon the combined patient and family data. Future identification of HNPCC will be facilitated by the introduction of genetic markers. Identification of HNPCC families is extremely important, because periodic examination may prevent development of disease and death from cancer.

Authors+Show Affiliations

The Netherlands Foundation for the Detection of Hereditary Tumours, Utrecht/Leiden.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

7979195

Citation

Vasen, H F.. "What Is Hereditary Nonpolyposis Colorectal Cancer (HNPCC)." Anticancer Research, vol. 14, no. 4B, 1994, pp. 1613-5.
Vasen HF. What is hereditary nonpolyposis colorectal cancer (HNPCC). Anticancer Res. 1994;14(4B):1613-5.
Vasen, H. F. (1994). What is hereditary nonpolyposis colorectal cancer (HNPCC). Anticancer Research, 14(4B), 1613-5.
Vasen HF. What Is Hereditary Nonpolyposis Colorectal Cancer (HNPCC). Anticancer Res. 1994 Jul-Aug;14(4B):1613-5. PubMed PMID: 7979195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What is hereditary nonpolyposis colorectal cancer (HNPCC). A1 - Vasen,H F, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 1613 EP - 5 JF - Anticancer research JO - Anticancer Res. VL - 14 IS - 4B N2 - Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominantly inherited disease associated with a marked increase in cancer susceptibility, especially cancer of the colorectum. It is one of the most common cancer predisposing syndromes affecting as many as one in 400 individuals in the Western World. Two (mismatch repair) genes (hMSH2 on chromosome 2p and hMLH1 on chromosome 3p) have recently been identified which appear to be involved in the development of cancer in most of the HNPCC families. Colorectal cancer in HNPCC differs from sporadic colorectal cancer by an early age of onset, a proclivity for the proximal colon, and an excess of synchronous and metachronous colorectal cancers. A variety of extracolonic tumors may be encountered in HNPCC, including cancers of the endometrium, stomach, small bowel, urinary tract (renal pelvis and ureter), biliary system and ovary. The diagnosis HNPCC is currently based upon the combined patient and family data. Future identification of HNPCC will be facilitated by the introduction of genetic markers. Identification of HNPCC families is extremely important, because periodic examination may prevent development of disease and death from cancer. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/7979195/What_is_hereditary_nonpolyposis_colorectal_cancer__HNPCC__ L2 - http://www.diseaseinfosearch.org/result/3345 DB - PRIME DP - Unbound Medicine ER -
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