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Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier.
Arch Int Pharmacodyn Ther. 1994 Mar-Apr; 327(2):220-31.AI

Abstract

The effect of an aqueous extract obtained from the roots of Valeriana officinalis was investigated on the uptake and release of GABA in synaptosomes isolated from rat brain cortex. Aqueous extract of valerian inhibited the uptake and stimulated the release of [3H]GABA, either in the absence or in the presence of K+ depolarization. The release was Na(+)-dependent and independent of the presence of Ca2+ in the external medium. It is concluded that valerian extract releases [3H]GABA by reversal of the GABA carrier, which is Na(+)-dependent and Ca(2+)-independent. This increase in [3H]GABA release appears to be independent from Na(+)-K(+)-ATPase activity and the membrane potential.

Authors+Show Affiliations

Santos MS
Department of Zoology, Faculty of Medicine, University of Coimbra, Portugal.
Ferreira F
No affiliation info available
Cunha AP
No affiliation info available
Carvalho AP
No affiliation info available
Ribeiro CF
No affiliation info available
Macedo T
No affiliation info available

MeSH

Amino AcidsAnimalsBrain ChemistryCarrier ProteinsCell MembraneCholineCytoplasmGABA Plasma Membrane Transport ProteinsIn Vitro TechniquesMaleMembrane PotentialsMembrane ProteinsMembrane Transport ProteinsOrganic Anion TransportersPlant ExtractsPlants, MedicinalPotassiumRatsRats, WistarSodium-Potassium-Exchanging ATPaseSynaptosomesValeriangamma-Aminobutyric Acid

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7979830

Citation

Santos, M S., et al. "Synaptosomal GABA Release as Influenced By Valerian Root Extract--involvement of the GABA Carrier." Archives Internationales De Pharmacodynamie Et De Therapie, vol. 327, no. 2, 1994, pp. 220-31.
Santos MS, Ferreira F, Cunha AP, et al. Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier. Arch Int Pharmacodyn Ther. 1994;327(2):220-31.
Santos, M. S., Ferreira, F., Cunha, A. P., Carvalho, A. P., Ribeiro, C. F., & Macedo, T. (1994). Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier. Archives Internationales De Pharmacodynamie Et De Therapie, 327(2), 220-31.
Santos MS, et al. Synaptosomal GABA Release as Influenced By Valerian Root Extract--involvement of the GABA Carrier. Arch Int Pharmacodyn Ther. 1994 Mar-Apr;327(2):220-31. PubMed PMID: 7979830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier. AU - Santos,M S, AU - Ferreira,F, AU - Cunha,A P, AU - Carvalho,A P, AU - Ribeiro,C F, AU - Macedo,T, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 220 EP - 31 JF - Archives internationales de pharmacodynamie et de therapie JO - Arch Int Pharmacodyn Ther VL - 327 IS - 2 N2 - The effect of an aqueous extract obtained from the roots of Valeriana officinalis was investigated on the uptake and release of GABA in synaptosomes isolated from rat brain cortex. Aqueous extract of valerian inhibited the uptake and stimulated the release of [3H]GABA, either in the absence or in the presence of K+ depolarization. The release was Na(+)-dependent and independent of the presence of Ca2+ in the external medium. It is concluded that valerian extract releases [3H]GABA by reversal of the GABA carrier, which is Na(+)-dependent and Ca(2+)-independent. This increase in [3H]GABA release appears to be independent from Na(+)-K(+)-ATPase activity and the membrane potential. SN - 0003-9780 UR - https://www.unboundmedicine.com/medline/citation/7979830/Synaptosomal_GABA_release_as_influenced_by_valerian_root_extract__involvement_of_the_GABA_carrier_ DB - PRIME DP - Unbound Medicine ER -