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Diagnosis of histoplasmosis by antigen detection during an outbreak in Indianapolis, Ind.
Arch Pathol Lab Med. 1994 Dec; 118(12):1205-8.AP

Abstract

In this study we examine the sensitivity of Histoplasma capsulatum var capsulatum antigen detection for the diagnosis of histoplasmosis. This was a retrospective review of the sensitivity of antigen detection in patients who were diagnosed as having self-limited, chronic pulmonary, or disseminated histoplasmosis during an outbreak in Indianapolis, Ind. All patients had clinical and laboratory evidence of histoplasmosis, and specimens of urine or serum that were obtained from the patients were tested for H capsulatum var capsulatum antigen. Of the 195 patients who were studied, the following forms of the infection were found: disseminated (n = 108), self-limited (n = 70), chronic pulmonary (n = 14), and asymptomatic (n = 3). Antigen was detected in 92%, 21%, and 39% of the patients with the disseminated, chronic pulmonary, and self-limited forms of histoplasmosis, respectively. Tests for the antigen are most useful in patients with clinical findings of disseminated infection. Antigen detection also may be useful in those patients with more severe pulmonary involvement, especially during the first month of illness when serologic tests for antibodies may be negative.

Authors+Show Affiliations

Department of Dermatology, Indiana University School of Medicine.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7979915

Citation

Williams, B, et al. "Diagnosis of Histoplasmosis By Antigen Detection During an Outbreak in Indianapolis, Ind." Archives of Pathology & Laboratory Medicine, vol. 118, no. 12, 1994, pp. 1205-8.
Williams B, Fojtasek M, Connolly-Stringfield P, et al. Diagnosis of histoplasmosis by antigen detection during an outbreak in Indianapolis, Ind. Arch Pathol Lab Med. 1994;118(12):1205-8.
Williams, B., Fojtasek, M., Connolly-Stringfield, P., & Wheat, J. (1994). Diagnosis of histoplasmosis by antigen detection during an outbreak in Indianapolis, Ind. Archives of Pathology & Laboratory Medicine, 118(12), 1205-8.
Williams B, et al. Diagnosis of Histoplasmosis By Antigen Detection During an Outbreak in Indianapolis, Ind. Arch Pathol Lab Med. 1994;118(12):1205-8. PubMed PMID: 7979915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of histoplasmosis by antigen detection during an outbreak in Indianapolis, Ind. AU - Williams,B, AU - Fojtasek,M, AU - Connolly-Stringfield,P, AU - Wheat,J, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 1205 EP - 8 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 118 IS - 12 N2 - In this study we examine the sensitivity of Histoplasma capsulatum var capsulatum antigen detection for the diagnosis of histoplasmosis. This was a retrospective review of the sensitivity of antigen detection in patients who were diagnosed as having self-limited, chronic pulmonary, or disseminated histoplasmosis during an outbreak in Indianapolis, Ind. All patients had clinical and laboratory evidence of histoplasmosis, and specimens of urine or serum that were obtained from the patients were tested for H capsulatum var capsulatum antigen. Of the 195 patients who were studied, the following forms of the infection were found: disseminated (n = 108), self-limited (n = 70), chronic pulmonary (n = 14), and asymptomatic (n = 3). Antigen was detected in 92%, 21%, and 39% of the patients with the disseminated, chronic pulmonary, and self-limited forms of histoplasmosis, respectively. Tests for the antigen are most useful in patients with clinical findings of disseminated infection. Antigen detection also may be useful in those patients with more severe pulmonary involvement, especially during the first month of illness when serologic tests for antibodies may be negative. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/7979915/Diagnosis_of_histoplasmosis_by_antigen_detection_during_an_outbreak_in_Indianapolis_Ind_ L2 - http://hivinsite.ucsf.edu/InSite?page=kb-05-02-06 DB - PRIME DP - Unbound Medicine ER -