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Radon-induced cancer: a cell-based model of tumorigenesis due to protracted exposures.
Int J Radiat Biol 1994; 66(5):649-53IJ

Abstract

In 1982, results with C3H mouse embryo cells showed that the frequency of neoplastic transformation was enhanced when exposures to fission-spectrum neutrons were protracted in time. This finding was unexpected because the opposite was found with low-LET radiations. Similar neutron enhancements were reported with normal life-span Syrian hamster embryo cells, and with human hybrid cells. Because other studies did not confirm the preceding, in 1990--at a conference convened by the US Armed Forces Radiobiological Research Institute--a biophysical model was proposed to explain the basis for the enhancement observed in some experiments but not in others. The model attributed special sensitivities, related to killing and neoplastic transformation, to cells in and around mitosis. Subsequently, it was shown that late G2/M phase cells constituted this window of sensitivity. In the instance of tumorigenesis, the model predicted that protracted exposures to a high-LET radiation would result in enhanced frequencies of transformation providing that susceptible cells were cycling or could be induced to cycle. The model explained data on lung tumour induction in rats breathing radon at different concentrations, and uranium miners working in atmospheres containing different concentrations of radon. The model also explains the anomalous finding that lung cancer deaths are often sublinearly correlated with indoor radon concentration.

Authors+Show Affiliations

Department of Radiological Health Sciences, Colorado State University, Fort Collins 80523.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

7983461

Citation

Elkind, M M.. "Radon-induced Cancer: a Cell-based Model of Tumorigenesis Due to Protracted Exposures." International Journal of Radiation Biology, vol. 66, no. 5, 1994, pp. 649-53.
Elkind MM. Radon-induced cancer: a cell-based model of tumorigenesis due to protracted exposures. Int J Radiat Biol. 1994;66(5):649-53.
Elkind, M. M. (1994). Radon-induced cancer: a cell-based model of tumorigenesis due to protracted exposures. International Journal of Radiation Biology, 66(5), pp. 649-53.
Elkind MM. Radon-induced Cancer: a Cell-based Model of Tumorigenesis Due to Protracted Exposures. Int J Radiat Biol. 1994;66(5):649-53. PubMed PMID: 7983461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radon-induced cancer: a cell-based model of tumorigenesis due to protracted exposures. A1 - Elkind,M M, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 649 EP - 53 JF - International journal of radiation biology JO - Int. J. Radiat. Biol. VL - 66 IS - 5 N2 - In 1982, results with C3H mouse embryo cells showed that the frequency of neoplastic transformation was enhanced when exposures to fission-spectrum neutrons were protracted in time. This finding was unexpected because the opposite was found with low-LET radiations. Similar neutron enhancements were reported with normal life-span Syrian hamster embryo cells, and with human hybrid cells. Because other studies did not confirm the preceding, in 1990--at a conference convened by the US Armed Forces Radiobiological Research Institute--a biophysical model was proposed to explain the basis for the enhancement observed in some experiments but not in others. The model attributed special sensitivities, related to killing and neoplastic transformation, to cells in and around mitosis. Subsequently, it was shown that late G2/M phase cells constituted this window of sensitivity. In the instance of tumorigenesis, the model predicted that protracted exposures to a high-LET radiation would result in enhanced frequencies of transformation providing that susceptible cells were cycling or could be induced to cycle. The model explained data on lung tumour induction in rats breathing radon at different concentrations, and uranium miners working in atmospheres containing different concentrations of radon. The model also explains the anomalous finding that lung cancer deaths are often sublinearly correlated with indoor radon concentration. SN - 0955-3002 UR - https://www.unboundmedicine.com/medline/citation/7983461/Radon-induced_cancer:_a_cell-based_model_of_tumorigenesis_due_to_protracted_exposures L2 - http://www.tandfonline.com/doi/full/10.1080/09553009414551771 DB - PRIME DP - Unbound Medicine ER -