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Effect on blood lipids, coagulation, and fibrinolysis of a fat high in myristic acid and a fat high in palmitic acid.
Am J Clin Nutr 1994; 60(6):919-25AJ

Abstract

The hypothesis that myristic acid (C14:0) has a stronger cholesterol-increasing potential than does palmitic acid is based on very few experimental observations. A randomized, strictly controlled dietary study was therefore designed to investigate the effect of a synthetic fat that was high in myristic acid, and palm oil, which is high in palmitic acid, on lipoproteins and hemostatic variables. Twelve men were served two diets (40% of energy as fat) with 41% of fat as myristic (diet M) or palmitic acid (diet P) for 3 wk with 1 mo between the two dietary schedules. Plasma HDL cholesterol was 8% higher with diet M than with diet P: 1.10 +/- 0.06 (mean +/- SEM) vs 1.01 +/- 0.05 mmol/L (P < 0.006). Diet M raised factor VII coagulant (F VIIc) activity to 98% (77-117%) vs 96% (71-109%) (medians and ranges) after diet P (P = 0.02). Total and LDL-cholesterol concentrations did not differ between the diets. In conclusion, the myristic acid test fat was not more cholesterolemic than was palm oil, but it did induce a minor rise in F VIIc activity.

Authors+Show Affiliations

Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7985634

Citation

Tholstrup, T, et al. "Effect On Blood Lipids, Coagulation, and Fibrinolysis of a Fat High in Myristic Acid and a Fat High in Palmitic Acid." The American Journal of Clinical Nutrition, vol. 60, no. 6, 1994, pp. 919-25.
Tholstrup T, Marckmann P, Jespersen J, et al. Effect on blood lipids, coagulation, and fibrinolysis of a fat high in myristic acid and a fat high in palmitic acid. Am J Clin Nutr. 1994;60(6):919-25.
Tholstrup, T., Marckmann, P., Jespersen, J., Vessby, B., Jart, A., & Sandström, B. (1994). Effect on blood lipids, coagulation, and fibrinolysis of a fat high in myristic acid and a fat high in palmitic acid. The American Journal of Clinical Nutrition, 60(6), pp. 919-25.
Tholstrup T, et al. Effect On Blood Lipids, Coagulation, and Fibrinolysis of a Fat High in Myristic Acid and a Fat High in Palmitic Acid. Am J Clin Nutr. 1994;60(6):919-25. PubMed PMID: 7985634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect on blood lipids, coagulation, and fibrinolysis of a fat high in myristic acid and a fat high in palmitic acid. AU - Tholstrup,T, AU - Marckmann,P, AU - Jespersen,J, AU - Vessby,B, AU - Jart,A, AU - Sandström,B, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 919 EP - 25 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 60 IS - 6 N2 - The hypothesis that myristic acid (C14:0) has a stronger cholesterol-increasing potential than does palmitic acid is based on very few experimental observations. A randomized, strictly controlled dietary study was therefore designed to investigate the effect of a synthetic fat that was high in myristic acid, and palm oil, which is high in palmitic acid, on lipoproteins and hemostatic variables. Twelve men were served two diets (40% of energy as fat) with 41% of fat as myristic (diet M) or palmitic acid (diet P) for 3 wk with 1 mo between the two dietary schedules. Plasma HDL cholesterol was 8% higher with diet M than with diet P: 1.10 +/- 0.06 (mean +/- SEM) vs 1.01 +/- 0.05 mmol/L (P < 0.006). Diet M raised factor VII coagulant (F VIIc) activity to 98% (77-117%) vs 96% (71-109%) (medians and ranges) after diet P (P = 0.02). Total and LDL-cholesterol concentrations did not differ between the diets. In conclusion, the myristic acid test fat was not more cholesterolemic than was palm oil, but it did induce a minor rise in F VIIc activity. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/7985634/Effect_on_blood_lipids_coagulation_and_fibrinolysis_of_a_fat_high_in_myristic_acid_and_a_fat_high_in_palmitic_acid_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/60.6.919 DB - PRIME DP - Unbound Medicine ER -