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Effect of the selective thromboxane A2 receptor antagonist, S-1452, on antigen-induced sustained bronchial hyperresponsiveness.
Eur J Pharmacol. 1994 Aug 01; 260(2-3):201-9.EJ

Abstract

Long-lasting bronchial hyperresponsiveness to i.v. acetylcholine was observed in actively sensitized guinea-pigs after aerosol ovalbumin exposure. The response became significant at 7 h post-challenge and persisted for at least 120 h compared to the response of unsensitized animals. Pretreatment of animals with the specific thromboxane A2 receptor antagonist, S-1452 (calcium (1R,2S,3S,4S)-(5Z)-7-(((phenylsulfonyl)amino)bicyclo[2.2.1] hept-2-yl)hept-5-enoate dihydrate), almost completely inhibited the onset of bronchial hyperresponsiveness, as assessed at 24 and 120 h post-challenge. However, it was ineffective when administered at 1 h post-challenge or 2 h before assessment of bronchial responsiveness. Lung vascular injury occurred transiently immediately after antigen challenge, the kinetics of injury being associated with those for the production of thromboxane B2 in bronchoalveolar lavage fluid. The vascular injury was dramatically suppressed by pretreatment with S-1452. These findings suggest that acutely generated thromboxane A2 plays an important role in the pathogenesis of antigen-induced long-lasting bronchial hyperresponsiveness, probably by producing vascular damage in the lungs.

Authors+Show Affiliations

Discovery Research Laboratories II, Shionogi & Co., Ltd. Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7988644

Citation

Arimura, A, et al. "Effect of the Selective Thromboxane A2 Receptor Antagonist, S-1452, On Antigen-induced Sustained Bronchial Hyperresponsiveness." European Journal of Pharmacology, vol. 260, no. 2-3, 1994, pp. 201-9.
Arimura A, Asanuma F, Matsumoto Y, et al. Effect of the selective thromboxane A2 receptor antagonist, S-1452, on antigen-induced sustained bronchial hyperresponsiveness. Eur J Pharmacol. 1994;260(2-3):201-9.
Arimura, A., Asanuma, F., Matsumoto, Y., Kurosawa, A., Jyoyama, H., & Nagai, H. (1994). Effect of the selective thromboxane A2 receptor antagonist, S-1452, on antigen-induced sustained bronchial hyperresponsiveness. European Journal of Pharmacology, 260(2-3), 201-9.
Arimura A, et al. Effect of the Selective Thromboxane A2 Receptor Antagonist, S-1452, On Antigen-induced Sustained Bronchial Hyperresponsiveness. Eur J Pharmacol. 1994 Aug 1;260(2-3):201-9. PubMed PMID: 7988644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the selective thromboxane A2 receptor antagonist, S-1452, on antigen-induced sustained bronchial hyperresponsiveness. AU - Arimura,A, AU - Asanuma,F, AU - Matsumoto,Y, AU - Kurosawa,A, AU - Jyoyama,H, AU - Nagai,H, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 201 EP - 9 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 260 IS - 2-3 N2 - Long-lasting bronchial hyperresponsiveness to i.v. acetylcholine was observed in actively sensitized guinea-pigs after aerosol ovalbumin exposure. The response became significant at 7 h post-challenge and persisted for at least 120 h compared to the response of unsensitized animals. Pretreatment of animals with the specific thromboxane A2 receptor antagonist, S-1452 (calcium (1R,2S,3S,4S)-(5Z)-7-(((phenylsulfonyl)amino)bicyclo[2.2.1] hept-2-yl)hept-5-enoate dihydrate), almost completely inhibited the onset of bronchial hyperresponsiveness, as assessed at 24 and 120 h post-challenge. However, it was ineffective when administered at 1 h post-challenge or 2 h before assessment of bronchial responsiveness. Lung vascular injury occurred transiently immediately after antigen challenge, the kinetics of injury being associated with those for the production of thromboxane B2 in bronchoalveolar lavage fluid. The vascular injury was dramatically suppressed by pretreatment with S-1452. These findings suggest that acutely generated thromboxane A2 plays an important role in the pathogenesis of antigen-induced long-lasting bronchial hyperresponsiveness, probably by producing vascular damage in the lungs. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/7988644/Effect_of_the_selective_thromboxane_A2_receptor_antagonist_S_1452_on_antigen_induced_sustained_bronchial_hyperresponsiveness_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-2999(94)90338-7 DB - PRIME DP - Unbound Medicine ER -