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Accumulation of trehalose in Saccharomyces cerevisiae growing on maltose is dependent on the TPS1 gene encoding the UDPglucose-linked trehalose synthase.
FEBS Lett. 1994 Dec 05; 355(3):309-13.FL

Abstract

When yeast strains were cultivated on maltose, the synthesis of trehalose already started in the exponential phase of growth, well before exhaustion of the sugar from the medium. This active pattern of trehalose accumulation was also observed in a maltose constitutive mutant strain growing on glucose. However, this accumulation was completely prevented by deletion of the TPS1 gene coding for the catalytic subunit of the UDPglucose-linked trehalose-6-phosphate synthase, indicating that no alternative pathway for trehalose synthesis exists in yeast. The active pattern of trehalose accumulation seems to be consistent with the finding that trehalose-6-phosphate synthase is more active in strains growing on maltose than on glucose.

Authors+Show Affiliations

Centre de Bioingenierie Gilbert Durand, URA CNRS 544, INRA, Institut National des Sciences Appliquées, Toulouse, France.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7988695

Citation

Petit, T, and J François. "Accumulation of Trehalose in Saccharomyces Cerevisiae Growing On Maltose Is Dependent On the TPS1 Gene Encoding the UDPglucose-linked Trehalose Synthase." FEBS Letters, vol. 355, no. 3, 1994, pp. 309-13.
Petit T, François J. Accumulation of trehalose in Saccharomyces cerevisiae growing on maltose is dependent on the TPS1 gene encoding the UDPglucose-linked trehalose synthase. FEBS Lett. 1994;355(3):309-13.
Petit, T., & François, J. (1994). Accumulation of trehalose in Saccharomyces cerevisiae growing on maltose is dependent on the TPS1 gene encoding the UDPglucose-linked trehalose synthase. FEBS Letters, 355(3), 309-13.
Petit T, François J. Accumulation of Trehalose in Saccharomyces Cerevisiae Growing On Maltose Is Dependent On the TPS1 Gene Encoding the UDPglucose-linked Trehalose Synthase. FEBS Lett. 1994 Dec 5;355(3):309-13. PubMed PMID: 7988695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accumulation of trehalose in Saccharomyces cerevisiae growing on maltose is dependent on the TPS1 gene encoding the UDPglucose-linked trehalose synthase. AU - Petit,T, AU - François,J, PY - 1994/12/5/pubmed PY - 1994/12/5/medline PY - 1994/12/5/entrez SP - 309 EP - 13 JF - FEBS letters JO - FEBS Lett. VL - 355 IS - 3 N2 - When yeast strains were cultivated on maltose, the synthesis of trehalose already started in the exponential phase of growth, well before exhaustion of the sugar from the medium. This active pattern of trehalose accumulation was also observed in a maltose constitutive mutant strain growing on glucose. However, this accumulation was completely prevented by deletion of the TPS1 gene coding for the catalytic subunit of the UDPglucose-linked trehalose-6-phosphate synthase, indicating that no alternative pathway for trehalose synthesis exists in yeast. The active pattern of trehalose accumulation seems to be consistent with the finding that trehalose-6-phosphate synthase is more active in strains growing on maltose than on glucose. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/7988695/Accumulation_of_trehalose_in_Saccharomyces_cerevisiae_growing_on_maltose_is_dependent_on_the_TPS1_gene_encoding_the_UDPglucose_linked_trehalose_synthase_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)01215-6 DB - PRIME DP - Unbound Medicine ER -