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Oral chloral hydrate provides effective and safe sedation in paediatric magnetic resonance imaging.
J Clin Pharm Ther 1994; 19(4):239-43JC

Abstract

Sedation is routinely required for successful Magnetic Resonance imaging in infants and children. Five hundred and ninety-six paediatric patients (270 female and 326 male, age (mean +/- SD) 41 +/- 30 months and weight 14.8 +/- 6.5 kg) entered an open, non-comparative, prospective study to assess oral chloral hydrate sedation in a large and homogeneous paediatric population undergoing Magnetic Resonance imaging. Chloral hydrate syrup 70 mg/ml was administered 20-40 min prior to the procedure. Effective sedation was reached in 94.1% with a total dose (mean +/- SEM) of 68 +/- 1 mg/kg (range 20-170 mg/kg). Statistical analysis of sedation failures vs. successful examinations after the total dose showed significant differences for dose (62 +/- 4 vs. 69 +/- 1 mg/kg; P < 0.05), age (64 +/- 7 vs. 40 +/- 1 months; P < 0.001) and weight (19.8 +/- 1.5 vs. 14.5 +/- 0.0 kg; P < 0.001). Effectiveness fell to around 80% in children with encephalic white matter alterations, medullary tumours or syringohydromyela (P = 0.07). The mean time of onset of sedation was 26 +/- 1 min, and the mean time to spontaneous awakening after the completion of the Magnetic Resonance examination was 38 +/- 2 min. Fifty-nine children (9.9%) experienced adverse reactions, with nausea and vomiting being the most common (n = 41), followed by nervousness and unusual excitement (n = 6). Discriminant function analysis identified age and total dose as the quantitative variables helping to differentiate between sedation failures and satisfactory examinations (sensitivity = 0.73, and specificity = 0.61; r = 0.20, P < 0.001).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

School of Pharmacy, Colegio Universitario CEU San Pablo, University of Valencia, Moncada, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7989402

Citation

Ronchera-Oms, C L., et al. "Oral Chloral Hydrate Provides Effective and Safe Sedation in Paediatric Magnetic Resonance Imaging." Journal of Clinical Pharmacy and Therapeutics, vol. 19, no. 4, 1994, pp. 239-43.
Ronchera-Oms CL, Casillas C, Martí-Bonmatí L, et al. Oral chloral hydrate provides effective and safe sedation in paediatric magnetic resonance imaging. J Clin Pharm Ther. 1994;19(4):239-43.
Ronchera-Oms, C. L., Casillas, C., Martí-Bonmatí, L., Poyatos, C., Tomás, J., Sobejano, A., & Jiménez, N. V. (1994). Oral chloral hydrate provides effective and safe sedation in paediatric magnetic resonance imaging. Journal of Clinical Pharmacy and Therapeutics, 19(4), pp. 239-43.
Ronchera-Oms CL, et al. Oral Chloral Hydrate Provides Effective and Safe Sedation in Paediatric Magnetic Resonance Imaging. J Clin Pharm Ther. 1994;19(4):239-43. PubMed PMID: 7989402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral chloral hydrate provides effective and safe sedation in paediatric magnetic resonance imaging. AU - Ronchera-Oms,C L, AU - Casillas,C, AU - Martí-Bonmatí,L, AU - Poyatos,C, AU - Tomás,J, AU - Sobejano,A, AU - Jiménez,N V, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 239 EP - 43 JF - Journal of clinical pharmacy and therapeutics JO - J Clin Pharm Ther VL - 19 IS - 4 N2 - Sedation is routinely required for successful Magnetic Resonance imaging in infants and children. Five hundred and ninety-six paediatric patients (270 female and 326 male, age (mean +/- SD) 41 +/- 30 months and weight 14.8 +/- 6.5 kg) entered an open, non-comparative, prospective study to assess oral chloral hydrate sedation in a large and homogeneous paediatric population undergoing Magnetic Resonance imaging. Chloral hydrate syrup 70 mg/ml was administered 20-40 min prior to the procedure. Effective sedation was reached in 94.1% with a total dose (mean +/- SEM) of 68 +/- 1 mg/kg (range 20-170 mg/kg). Statistical analysis of sedation failures vs. successful examinations after the total dose showed significant differences for dose (62 +/- 4 vs. 69 +/- 1 mg/kg; P < 0.05), age (64 +/- 7 vs. 40 +/- 1 months; P < 0.001) and weight (19.8 +/- 1.5 vs. 14.5 +/- 0.0 kg; P < 0.001). Effectiveness fell to around 80% in children with encephalic white matter alterations, medullary tumours or syringohydromyela (P = 0.07). The mean time of onset of sedation was 26 +/- 1 min, and the mean time to spontaneous awakening after the completion of the Magnetic Resonance examination was 38 +/- 2 min. Fifty-nine children (9.9%) experienced adverse reactions, with nausea and vomiting being the most common (n = 41), followed by nervousness and unusual excitement (n = 6). Discriminant function analysis identified age and total dose as the quantitative variables helping to differentiate between sedation failures and satisfactory examinations (sensitivity = 0.73, and specificity = 0.61; r = 0.20, P < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0269-4727 UR - https://www.unboundmedicine.com/medline/citation/7989402/Oral_chloral_hydrate_provides_effective_and_safe_sedation_in_paediatric_magnetic_resonance_imaging_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-4727&amp;date=1994&amp;volume=19&amp;issue=4&amp;spage=239 DB - PRIME DP - Unbound Medicine ER -