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[Megaloblastic anemia in children].
Arch Pediatr. 1994 Mar; 1(3):281-8.AP

Abstract

Megaloblastic anemia in children is mainly due to folic acid or vitamin B12 deficiencies. However dosages of these two vitamins must be performed before any vitamin supplementation or blood transfusions are given in order to establish precisely the etiologic diagnosis. A disorder in the metabolism of these vitamins must be considered in any infants in whom the onset of neurological abnormalities is associated with the characteristic hematological abnormalities. Imerslund's syndrome is a specific vitamin B12 malabsorption defect that warrants consideration as it is easy to recognize on the basis of the association of megaloblastic anemia and proteinuria. A possible drug-induced etiology must also be looked for. In the absence of vitamin deficiency, several rare etiologies must be considered. A macrocytosis, occasionally with megaloblastosis reflecting an abnormal erythropoiesis, may accompany an hemopathy, eventually malignant.

Authors+Show Affiliations

Service de pédiatrie I, CHU Dupuytren, Limoges, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

7994338

Citation

de Lumley, L, et al. "[Megaloblastic Anemia in Children]." Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, vol. 1, no. 3, 1994, pp. 281-8.
de Lumley L, Boulesteix J, Borreda D, et al. [Megaloblastic anemia in children]. Arch Pediatr. 1994;1(3):281-8.
de Lumley, L., Boulesteix, J., Borreda, D., Tuel, M. C., & Gilbert, B. (1994). [Megaloblastic anemia in children]. Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, 1(3), 281-8.
de Lumley L, et al. [Megaloblastic Anemia in Children]. Arch Pediatr. 1994;1(3):281-8. PubMed PMID: 7994338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Megaloblastic anemia in children]. AU - de Lumley,L, AU - Boulesteix,J, AU - Borreda,D, AU - Tuel,M C, AU - Gilbert,B, PY - 1994/3/1/pubmed PY - 2000/5/5/medline PY - 1994/3/1/entrez SP - 281 EP - 8 JF - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie JO - Arch Pediatr VL - 1 IS - 3 N2 - Megaloblastic anemia in children is mainly due to folic acid or vitamin B12 deficiencies. However dosages of these two vitamins must be performed before any vitamin supplementation or blood transfusions are given in order to establish precisely the etiologic diagnosis. A disorder in the metabolism of these vitamins must be considered in any infants in whom the onset of neurological abnormalities is associated with the characteristic hematological abnormalities. Imerslund's syndrome is a specific vitamin B12 malabsorption defect that warrants consideration as it is easy to recognize on the basis of the association of megaloblastic anemia and proteinuria. A possible drug-induced etiology must also be looked for. In the absence of vitamin deficiency, several rare etiologies must be considered. A macrocytosis, occasionally with megaloblastosis reflecting an abnormal erythropoiesis, may accompany an hemopathy, eventually malignant. SN - 0929-693X UR - https://www.unboundmedicine.com/medline/citation/7994338/[Megaloblastic_anemia_in_children]_ L2 - http://www.diseaseinfosearch.org/result/4562 DB - PRIME DP - Unbound Medicine ER -