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Lack of adverse reactions to measles, mumps, and rubella vaccine in egg-allergic children.
Ann Allergy 1994; 73(6):486-8AA

Abstract

BACKGROUND

Controversy exists regarding allergic reactions to measles, mumps, and rubella (MMR) vaccine in egg-allergic patients. To date there have been only isolated reports describing egg-allergic patients with anaphylaxis to MMR vaccine.

OBJECTIVE

Our study was designed to monitor possible adverse reactions in egg-allergic children receiving MMR vaccine.

METHODS

Initially prick and intradermal testing with MMR vaccine was carried out. The first 120 children were screened in this fashion, with frequent irritant reactions occurring with skin testing but no subsequent reactions when full-strength vaccine was administered. The subsequent 380 children received the undiluted MMR vaccine without prior skin testing.

DESIGN

Over an 8-year period, MMR vaccine was given to 500 egg-allergic children in outpatient setting.

RESULTS

No anaphylactic reactions were observed in any of the 500 children immunized with MMR vaccine. Five children showed minor rashes within two hours of administration of the MMR vaccine.

CONCLUSIONS

It is therefore felt the previously reported adverse reactions to MMR vaccine represent reactions to other vaccine components rather than the suspected egg antigens. The presence of egg allergy should therefore not be considered a contraindication to MMR immunization.

Authors+Show Affiliations

Department of Pediatrics, Faculty of Medicine, University of Calgary, AB, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7998661

Citation

Freigang, B, et al. "Lack of Adverse Reactions to Measles, Mumps, and Rubella Vaccine in Egg-allergic Children." Annals of Allergy, vol. 73, no. 6, 1994, pp. 486-8.
Freigang B, Jadavji TP, Freigang DW. Lack of adverse reactions to measles, mumps, and rubella vaccine in egg-allergic children. Ann Allergy. 1994;73(6):486-8.
Freigang, B., Jadavji, T. P., & Freigang, D. W. (1994). Lack of adverse reactions to measles, mumps, and rubella vaccine in egg-allergic children. Annals of Allergy, 73(6), pp. 486-8.
Freigang B, Jadavji TP, Freigang DW. Lack of Adverse Reactions to Measles, Mumps, and Rubella Vaccine in Egg-allergic Children. Ann Allergy. 1994;73(6):486-8. PubMed PMID: 7998661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of adverse reactions to measles, mumps, and rubella vaccine in egg-allergic children. AU - Freigang,B, AU - Jadavji,T P, AU - Freigang,D W, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 486 EP - 8 JF - Annals of allergy JO - Ann Allergy VL - 73 IS - 6 N2 - BACKGROUND: Controversy exists regarding allergic reactions to measles, mumps, and rubella (MMR) vaccine in egg-allergic patients. To date there have been only isolated reports describing egg-allergic patients with anaphylaxis to MMR vaccine. OBJECTIVE: Our study was designed to monitor possible adverse reactions in egg-allergic children receiving MMR vaccine. METHODS: Initially prick and intradermal testing with MMR vaccine was carried out. The first 120 children were screened in this fashion, with frequent irritant reactions occurring with skin testing but no subsequent reactions when full-strength vaccine was administered. The subsequent 380 children received the undiluted MMR vaccine without prior skin testing. DESIGN: Over an 8-year period, MMR vaccine was given to 500 egg-allergic children in outpatient setting. RESULTS: No anaphylactic reactions were observed in any of the 500 children immunized with MMR vaccine. Five children showed minor rashes within two hours of administration of the MMR vaccine. CONCLUSIONS: It is therefore felt the previously reported adverse reactions to MMR vaccine represent reactions to other vaccine components rather than the suspected egg antigens. The presence of egg allergy should therefore not be considered a contraindication to MMR immunization. SN - 0003-4738 UR - https://www.unboundmedicine.com/medline/citation/7998661/Lack_of_adverse_reactions_to_measles_mumps_and_rubella_vaccine_in_egg_allergic_children_ L2 - http://www.diseaseinfosearch.org/result/6369 DB - PRIME DP - Unbound Medicine ER -