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Predictive value of apolipoprotein E genotyping in Alzheimer's disease: results of an autopsy series and an analysis of several combined studies.
Ann Neurol 1994; 36(6):889-95AN

Abstract

Apoliprotein E (apoE) is associated with Alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques. Recent studies have shown an increased frequency of the epsilon 4 allele of the apoE gene in familial and sporadic cases of Alzheimer's disease (AD). In the present case control study, we have determined the apoE genotype by allele-specific extension of 113 postmortem cases of sporadic AD and 77 control brains shown to be free of AD neuropathological features and then calculated the frequency of the various allelic forms of apoE (epsilon 2, epsilon 3, epsilon 4). The odds ratio associating epsilon 4 with AD was 15.5 (95% confidence interval [CI] 6.2-38.5), and the population attributable risk was 0.53. We have also combined the results of our study and several others to calculate these same parameters in a larger population (570 controls and 961 AD subjects); the odds ratio for this larger group was 6.2 (95% CI 4.9-7.8) and the population attributable risk was 0.57. These results further substantiate and strengthen the association between the epsilon 4 allele of apoE gene and AD. We have also used these results to investigate the usefulness of the determination of epsilon 4 carrier status in the diagnosis of AD.

Authors+Show Affiliations

McGill Centre for Studies in Aging, Verdun, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7998776

Citation

Nalbantoglu, J, et al. "Predictive Value of Apolipoprotein E Genotyping in Alzheimer's Disease: Results of an Autopsy Series and an Analysis of Several Combined Studies." Annals of Neurology, vol. 36, no. 6, 1994, pp. 889-95.
Nalbantoglu J, Gilfix BM, Bertrand P, et al. Predictive value of apolipoprotein E genotyping in Alzheimer's disease: results of an autopsy series and an analysis of several combined studies. Ann Neurol. 1994;36(6):889-95.
Nalbantoglu, J., Gilfix, B. M., Bertrand, P., Robitaille, Y., Gauthier, S., Rosenblatt, D. S., & Poirier, J. (1994). Predictive value of apolipoprotein E genotyping in Alzheimer's disease: results of an autopsy series and an analysis of several combined studies. Annals of Neurology, 36(6), pp. 889-95.
Nalbantoglu J, et al. Predictive Value of Apolipoprotein E Genotyping in Alzheimer's Disease: Results of an Autopsy Series and an Analysis of Several Combined Studies. Ann Neurol. 1994;36(6):889-95. PubMed PMID: 7998776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive value of apolipoprotein E genotyping in Alzheimer's disease: results of an autopsy series and an analysis of several combined studies. AU - Nalbantoglu,J, AU - Gilfix,B M, AU - Bertrand,P, AU - Robitaille,Y, AU - Gauthier,S, AU - Rosenblatt,D S, AU - Poirier,J, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 889 EP - 95 JF - Annals of neurology JO - Ann. Neurol. VL - 36 IS - 6 N2 - Apoliprotein E (apoE) is associated with Alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques. Recent studies have shown an increased frequency of the epsilon 4 allele of the apoE gene in familial and sporadic cases of Alzheimer's disease (AD). In the present case control study, we have determined the apoE genotype by allele-specific extension of 113 postmortem cases of sporadic AD and 77 control brains shown to be free of AD neuropathological features and then calculated the frequency of the various allelic forms of apoE (epsilon 2, epsilon 3, epsilon 4). The odds ratio associating epsilon 4 with AD was 15.5 (95% confidence interval [CI] 6.2-38.5), and the population attributable risk was 0.53. We have also combined the results of our study and several others to calculate these same parameters in a larger population (570 controls and 961 AD subjects); the odds ratio for this larger group was 6.2 (95% CI 4.9-7.8) and the population attributable risk was 0.57. These results further substantiate and strengthen the association between the epsilon 4 allele of apoE gene and AD. We have also used these results to investigate the usefulness of the determination of epsilon 4 carrier status in the diagnosis of AD. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/7998776/Predictive_value_of_apolipoprotein_E_genotyping_in_Alzheimer's_disease:_results_of_an_autopsy_series_and_an_analysis_of_several_combined_studies_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1994&volume=36&issue=6&spage=889 DB - PRIME DP - Unbound Medicine ER -