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Human cowpox 1969-93: a review based on 54 cases.
Br J Dermatol. 1994 Nov; 131(5):598-607.BJ

Abstract

This survey of the clinical and epidemiological features of human cowpox, a rare but relatively severe zoonotic infection, is based on 54 cases, many unpublished, which we have studied since 1969. Patients present with painful, haemorrhagic pustules or black eschars, usually on the hand or face, accompanied by oedema, erythema, lymphadenopathy, and systemic involvement. Severe, occasionally fatal, cases occur in eczematous and immunosuppressed individuals, although cowpox has not yet been reported in anyone infected with the human immunodeficiency virus. Variations in the clinical features are described, and the differential clinical diagnosis of cowpox, parapox, herpes virus, and anthrax infections is discussed. The role of the laboratory in diagnosis is described, and the value of electron microscopy in providing rapid confirmation is emphasized. Care in taking a detailed history will assist in the initial clinical diagnosis, and a history of contact with domestic cats, particularly during July-October, is important. The possible influence of smallpox vaccination on the incidence and severity is discussed and discounted.

Authors+Show Affiliations

Department of Medical Microbiology, Liverpool University, U.K.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

7999588

Citation

Baxby, D, et al. "Human Cowpox 1969-93: a Review Based On 54 Cases." The British Journal of Dermatology, vol. 131, no. 5, 1994, pp. 598-607.
Baxby D, Bennett M, Getty B. Human cowpox 1969-93: a review based on 54 cases. Br J Dermatol. 1994;131(5):598-607.
Baxby, D., Bennett, M., & Getty, B. (1994). Human cowpox 1969-93: a review based on 54 cases. The British Journal of Dermatology, 131(5), 598-607.
Baxby D, Bennett M, Getty B. Human Cowpox 1969-93: a Review Based On 54 Cases. Br J Dermatol. 1994;131(5):598-607. PubMed PMID: 7999588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human cowpox 1969-93: a review based on 54 cases. AU - Baxby,D, AU - Bennett,M, AU - Getty,B, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 598 EP - 607 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 131 IS - 5 N2 - This survey of the clinical and epidemiological features of human cowpox, a rare but relatively severe zoonotic infection, is based on 54 cases, many unpublished, which we have studied since 1969. Patients present with painful, haemorrhagic pustules or black eschars, usually on the hand or face, accompanied by oedema, erythema, lymphadenopathy, and systemic involvement. Severe, occasionally fatal, cases occur in eczematous and immunosuppressed individuals, although cowpox has not yet been reported in anyone infected with the human immunodeficiency virus. Variations in the clinical features are described, and the differential clinical diagnosis of cowpox, parapox, herpes virus, and anthrax infections is discussed. The role of the laboratory in diagnosis is described, and the value of electron microscopy in providing rapid confirmation is emphasized. Care in taking a detailed history will assist in the initial clinical diagnosis, and a history of contact with domestic cats, particularly during July-October, is important. The possible influence of smallpox vaccination on the incidence and severity is discussed and discounted. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/7999588/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1994&volume=131&issue=5&spage=598 DB - PRIME DP - Unbound Medicine ER -