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Long-term effect of oral calcitriol single weekly pulse in CAPD and in HD.
Adv Perit Dial. 1994; 10:267-9.AP

Abstract

This study was undertaken to evaluate the long-term effect of single weekly oral pulse calcitriol therapy (0.05 mcg/kg) in 16 uremic patients. Eight (5 female, 3 male; aged 51.6 +/- 8.5 years) were on continuous ambulatory peritoneal dialysis (CAPD) for 28.8 +/- 12.7 months with basal intact parathyroid hormone (iPTH) 247 +/- 60 pg/mL. Eight (6 female, 2 male; aged 53 +/- 17.9 years) were on hemodialysis (HD) for 76.3 +/- 55 months with basal iPTH 270.9 +/- 92. Calcium dialysate was 1.75 mmol/L in all patients and serum phosphorus was controlled with CaCO3 2-4 g/day. Ca and P were measured weekly; iPTH and alkaline phosphatase were measured monthly. After two months, iPTH decreased to 132.4 +/- 89 (p < 0.05 vs basal values) in the HD patients and to 158.2 +/- 61 (p < 0.05) in the CAPD group. After six months, iPTH decreased to 108.6 +/- 73.2 (p < 0.01) in the HD patients and to 126.5 +/- 48 (p < 0.01) in the CAPD patients. Two patients (1 HD and 1 CAPD) who were not compliant with phosphate binder therapy were dropped. To control hyperphosphatemia in 1 HD patient we reduced bolus to 0.03 mcg/kg. Two CAPD patients presented hypercalcemia and required calcium dialysate of 1.25 mmol/L. In conclusion, single weekly oral pulse of calcitriol appears to be effective in suppressing mild hyperparathyroidism both in CAPD and in HD patients, even though some variations in the protocols may be required.

Authors+Show Affiliations

Nephrology and Dialysis Unit, Presidio Ospedaliero di Vigevano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7999842

Citation

Romanini, D, et al. "Long-term Effect of Oral Calcitriol Single Weekly Pulse in CAPD and in HD." Advances in Peritoneal Dialysis. Conference On Peritoneal Dialysis, vol. 10, 1994, pp. 267-9.
Romanini D, Gazo A, Bellazzi R, et al. Long-term effect of oral calcitriol single weekly pulse in CAPD and in HD. Adv Perit Dial. 1994;10:267-9.
Romanini, D., Gazo, A., Bellazzi, R., de Vincenzi, A., Nai, M., & Santagostino, M. (1994). Long-term effect of oral calcitriol single weekly pulse in CAPD and in HD. Advances in Peritoneal Dialysis. Conference On Peritoneal Dialysis, 10, 267-9.
Romanini D, et al. Long-term Effect of Oral Calcitriol Single Weekly Pulse in CAPD and in HD. Adv Perit Dial. 1994;10:267-9. PubMed PMID: 7999842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term effect of oral calcitriol single weekly pulse in CAPD and in HD. AU - Romanini,D, AU - Gazo,A, AU - Bellazzi,R, AU - de Vincenzi,A, AU - Nai,M, AU - Santagostino,M, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 267 EP - 9 JF - Advances in peritoneal dialysis. Conference on Peritoneal Dialysis JO - Adv Perit Dial VL - 10 N2 - This study was undertaken to evaluate the long-term effect of single weekly oral pulse calcitriol therapy (0.05 mcg/kg) in 16 uremic patients. Eight (5 female, 3 male; aged 51.6 +/- 8.5 years) were on continuous ambulatory peritoneal dialysis (CAPD) for 28.8 +/- 12.7 months with basal intact parathyroid hormone (iPTH) 247 +/- 60 pg/mL. Eight (6 female, 2 male; aged 53 +/- 17.9 years) were on hemodialysis (HD) for 76.3 +/- 55 months with basal iPTH 270.9 +/- 92. Calcium dialysate was 1.75 mmol/L in all patients and serum phosphorus was controlled with CaCO3 2-4 g/day. Ca and P were measured weekly; iPTH and alkaline phosphatase were measured monthly. After two months, iPTH decreased to 132.4 +/- 89 (p < 0.05 vs basal values) in the HD patients and to 158.2 +/- 61 (p < 0.05) in the CAPD group. After six months, iPTH decreased to 108.6 +/- 73.2 (p < 0.01) in the HD patients and to 126.5 +/- 48 (p < 0.01) in the CAPD patients. Two patients (1 HD and 1 CAPD) who were not compliant with phosphate binder therapy were dropped. To control hyperphosphatemia in 1 HD patient we reduced bolus to 0.03 mcg/kg. Two CAPD patients presented hypercalcemia and required calcium dialysate of 1.25 mmol/L. In conclusion, single weekly oral pulse of calcitriol appears to be effective in suppressing mild hyperparathyroidism both in CAPD and in HD patients, even though some variations in the protocols may be required. SN - 1197-8554 UR - https://www.unboundmedicine.com/medline/citation/7999842/Long_term_effect_of_oral_calcitriol_single_weekly_pulse_in_CAPD_and_in_HD_ L2 - https://medlineplus.gov/dialysis.html DB - PRIME DP - Unbound Medicine ER -