Tags

Type your tag names separated by a space and hit enter

CD4/CD8 lineage commitment in T cell receptor transgenic mice: evidence for precommitment of CD4+ CD8+ thymocytes.
Semin Immunol. 1994 Aug; 6(4):249-56.SI

Abstract

CD4+ and CD8+ mature T cells arise from CD4+ CD8+ thymic precursors by a process of positive selection that ultimately requires interaction of the T cell receptor (TCR) with self major histocompatibility complex (MHC) molecules. The mechanism of commitment of immature CD4+ CD8+ thymocytes to CD4 or CD8 lineages is controversial. Using TCR transgenic mice, we present evidence that CD4+ CD8+ thymocytes are precommitted to either the CD4 or CD8 lineage, prior to positive selection and independently of TCR specificity for MHC. This lineage precommitment model places important constraints on signaling via CD4 or CD8 coreceptor molecules.

Authors+Show Affiliations

Ludwig Institute for Cancer Research, Lausanne Branch, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8000034

Citation

Crompton, T, et al. "CD4/CD8 Lineage Commitment in T Cell Receptor Transgenic Mice: Evidence for Precommitment of CD4+ CD8+ Thymocytes." Seminars in Immunology, vol. 6, no. 4, 1994, pp. 249-56.
Crompton T, Hefti H, Lees RK, et al. CD4/CD8 lineage commitment in T cell receptor transgenic mice: evidence for precommitment of CD4+ CD8+ thymocytes. Semin Immunol. 1994;6(4):249-56.
Crompton, T., Hefti, H., Lees, R. K., Pircher, H., & MacDonald, H. R. (1994). CD4/CD8 lineage commitment in T cell receptor transgenic mice: evidence for precommitment of CD4+ CD8+ thymocytes. Seminars in Immunology, 6(4), 249-56.
Crompton T, et al. CD4/CD8 Lineage Commitment in T Cell Receptor Transgenic Mice: Evidence for Precommitment of CD4+ CD8+ Thymocytes. Semin Immunol. 1994;6(4):249-56. PubMed PMID: 8000034.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD4/CD8 lineage commitment in T cell receptor transgenic mice: evidence for precommitment of CD4+ CD8+ thymocytes. AU - Crompton,T, AU - Hefti,H, AU - Lees,R K, AU - Pircher,H, AU - MacDonald,H R, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 249 EP - 56 JF - Seminars in immunology JO - Semin Immunol VL - 6 IS - 4 N2 - CD4+ and CD8+ mature T cells arise from CD4+ CD8+ thymic precursors by a process of positive selection that ultimately requires interaction of the T cell receptor (TCR) with self major histocompatibility complex (MHC) molecules. The mechanism of commitment of immature CD4+ CD8+ thymocytes to CD4 or CD8 lineages is controversial. Using TCR transgenic mice, we present evidence that CD4+ CD8+ thymocytes are precommitted to either the CD4 or CD8 lineage, prior to positive selection and independently of TCR specificity for MHC. This lineage precommitment model places important constraints on signaling via CD4 or CD8 coreceptor molecules. SN - 1044-5323 UR - https://www.unboundmedicine.com/medline/citation/8000034/CD4/CD8_lineage_commitment_in_T_cell_receptor_transgenic_mice:_evidence_for_precommitment_of_CD4+_CD8+_thymocytes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1044-5323(84)71032-3 DB - PRIME DP - Unbound Medicine ER -