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Risk factors for childhood acute non-lymphocytic leukemia: an association with maternal alcohol consumption during pregnancy?
Cancer Epidemiol Biomarkers Prev. 1994 Sep; 3(6):457-60.CE

Abstract

A population-based case-control study of acute non-lymphocytic leukemia (ANLL) was performed with 80 ANLL cases diagnosed between 1973 and 1979, who were derived from the nationwide register of the Dutch Childhood Leukemia Study Group. Cases were compared to three age- and sex-matched population controls and, in order to control for recall bias, to 517 cases with acute lymphocytic leukemia from the same study base. Information on a large number of exposures to putative risk factors was collected by a self-administered questionnaire mailed to the parents. No significant association of ANLL was observed with smoking habits of the mother during pregnancy, ultrasound examinations, prenatal exposure to x-rays, viral infections, or hydrocarbon exposure. When comparing ANLL cases to population controls, maternal use of alcohol during pregnancy was associated with a more than two-fold increased risk of ANLL (odds ratio = 2.6; 95% confidence interval = 1.4-4.6). A similar increase in risk was found when comparing ANLL cases to acute lymphocytic leukemia cases. There was no significant elevation in risk for ANLL found for parental use of alcohol 1 year before pregnancy. This study suggests that intrauterine exposure to alcohol may increase the risk for childhood ANLL.

Authors+Show Affiliations

Dutch Childhood Leukemia Study Group, The Hague, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8000294

Citation

van Duijn, C M., et al. "Risk Factors for Childhood Acute Non-lymphocytic Leukemia: an Association With Maternal Alcohol Consumption During Pregnancy?" Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 3, no. 6, 1994, pp. 457-60.
van Duijn CM, van Steensel-Moll HA, Coebergh JW, et al. Risk factors for childhood acute non-lymphocytic leukemia: an association with maternal alcohol consumption during pregnancy? Cancer Epidemiol Biomarkers Prev. 1994;3(6):457-60.
van Duijn, C. M., van Steensel-Moll, H. A., Coebergh, J. W., & van Zanen, G. E. (1994). Risk factors for childhood acute non-lymphocytic leukemia: an association with maternal alcohol consumption during pregnancy? Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 3(6), 457-60.
van Duijn CM, et al. Risk Factors for Childhood Acute Non-lymphocytic Leukemia: an Association With Maternal Alcohol Consumption During Pregnancy. Cancer Epidemiol Biomarkers Prev. 1994;3(6):457-60. PubMed PMID: 8000294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for childhood acute non-lymphocytic leukemia: an association with maternal alcohol consumption during pregnancy? AU - van Duijn,C M, AU - van Steensel-Moll,H A, AU - Coebergh,J W, AU - van Zanen,G E, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 457 EP - 60 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 3 IS - 6 N2 - A population-based case-control study of acute non-lymphocytic leukemia (ANLL) was performed with 80 ANLL cases diagnosed between 1973 and 1979, who were derived from the nationwide register of the Dutch Childhood Leukemia Study Group. Cases were compared to three age- and sex-matched population controls and, in order to control for recall bias, to 517 cases with acute lymphocytic leukemia from the same study base. Information on a large number of exposures to putative risk factors was collected by a self-administered questionnaire mailed to the parents. No significant association of ANLL was observed with smoking habits of the mother during pregnancy, ultrasound examinations, prenatal exposure to x-rays, viral infections, or hydrocarbon exposure. When comparing ANLL cases to population controls, maternal use of alcohol during pregnancy was associated with a more than two-fold increased risk of ANLL (odds ratio = 2.6; 95% confidence interval = 1.4-4.6). A similar increase in risk was found when comparing ANLL cases to acute lymphocytic leukemia cases. There was no significant elevation in risk for ANLL found for parental use of alcohol 1 year before pregnancy. This study suggests that intrauterine exposure to alcohol may increase the risk for childhood ANLL. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/8000294/Risk_factors_for_childhood_acute_non_lymphocytic_leukemia:_an_association_with_maternal_alcohol_consumption_during_pregnancy L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=8000294 DB - PRIME DP - Unbound Medicine ER -