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Sibling pair analysis shows no linkage of generalized osteoarthritis to the loci encoding type II collagen, cartilage link protein or cartilage matrix protein.
Br J Rheumatol. 1994 Dec; 33(12):1103-6.BJ

Abstract

Generalized OA (GOA) is a well-characterized subset of primary OA which is strongly associated with the occurrence of Heberden's nodes. Using gene-specific highly polymorphic markers and affected sib pair (ASP) analyses, we have investigated genetic linkage between GOA and three cartilage matrix genes: COL2A1 which encodes type II collagen; CRTL1 which encodes the cartilage link protein and CRTM which encodes the cartilage matrix protein. The analyses showed no linkage between GOA and the three genes in the 38 sib pairs examined. Since we examined a relatively modest number of sib pairs, our results can only exclude COL2A1, CRTL1 and CRTM as major susceptibility loci for GOA.

Authors+Show Affiliations

Loughlin J
University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital.
Irven C
No affiliation info available
Fergusson C
No affiliation info available
Sykes B
No affiliation info available

MeSH

AllelesCartilage Oligomeric Matrix ProteinCollagenDiseases in TwinsExtracellular Matrix ProteinsFamily HealthGenetic LinkageGenetic MarkersGenetic Predisposition to DiseaseGenotypeGlycoproteinsHumansMatrilin ProteinsOsteoarthritisPolymorphism, GeneticProteinsProteoglycans

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8000735

Citation

Loughlin, J, et al. "Sibling Pair Analysis Shows No Linkage of Generalized Osteoarthritis to the Loci Encoding Type II Collagen, Cartilage Link Protein or Cartilage Matrix Protein." British Journal of Rheumatology, vol. 33, no. 12, 1994, pp. 1103-6.
Loughlin J, Irven C, Fergusson C, et al. Sibling pair analysis shows no linkage of generalized osteoarthritis to the loci encoding type II collagen, cartilage link protein or cartilage matrix protein. Br J Rheumatol. 1994;33(12):1103-6.
Loughlin, J., Irven, C., Fergusson, C., & Sykes, B. (1994). Sibling pair analysis shows no linkage of generalized osteoarthritis to the loci encoding type II collagen, cartilage link protein or cartilage matrix protein. British Journal of Rheumatology, 33(12), 1103-6.
Loughlin J, et al. Sibling Pair Analysis Shows No Linkage of Generalized Osteoarthritis to the Loci Encoding Type II Collagen, Cartilage Link Protein or Cartilage Matrix Protein. Br J Rheumatol. 1994;33(12):1103-6. PubMed PMID: 8000735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sibling pair analysis shows no linkage of generalized osteoarthritis to the loci encoding type II collagen, cartilage link protein or cartilage matrix protein. AU - Loughlin,J, AU - Irven,C, AU - Fergusson,C, AU - Sykes,B, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 1103 EP - 6 JF - British journal of rheumatology JO - Br J Rheumatol VL - 33 IS - 12 N2 - Generalized OA (GOA) is a well-characterized subset of primary OA which is strongly associated with the occurrence of Heberden's nodes. Using gene-specific highly polymorphic markers and affected sib pair (ASP) analyses, we have investigated genetic linkage between GOA and three cartilage matrix genes: COL2A1 which encodes type II collagen; CRTL1 which encodes the cartilage link protein and CRTM which encodes the cartilage matrix protein. The analyses showed no linkage between GOA and the three genes in the 38 sib pairs examined. Since we examined a relatively modest number of sib pairs, our results can only exclude COL2A1, CRTL1 and CRTM as major susceptibility loci for GOA. SN - 0263-7103 UR - https://www.unboundmedicine.com/medline/citation/8000735/Sibling_pair_analysis_shows_no_linkage_of_generalized_osteoarthritis_to_the_loci_encoding_type_II_collagen_cartilage_link_protein_or_cartilage_matrix_protein_ L2 - https://medlineplus.gov/osteoarthritis.html DB - PRIME DP - Unbound Medicine ER -