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[Artificial and bioartificial pancreas for the treatment of diabetes mellitus].
Diabete Metab. 1994; 20(2 Pt 2):183-93.DM

Abstract

The development of an artificial pancreas, a system in which insulin delivery would be regulated continuously by concomitant glucose levels, has been for a long time considered as a dream by diabetologists and diabetic patients. Two approaches are possible. The first one, electromechanical, consists of a glucose sensor, a computer and an insulin pump. Its development may be hindered by the inadequate biocompatibility of the glucose sensor. This led to consider at first the use of a disposable glucose sensor as part of a continuous glucose monitoring system. The second approach aims at developing a bioartificial pancreas, in which isolated islets of Langerhans would be protected against immune rejection by an artificial membrane permeable to glucose and insulin but not so to factors responsible for immune rejection. Thus, it may become possible to transplant a large number of patients before the onset of diabetic complications with xenogeneic islets, without need for any immunosuppression. Promises and obstacles of these two approaches are described herein.

Authors+Show Affiliations

INSERM U341, Service de Diabétologie, Hôtel-Dieu, Paris, France.

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

8001705

Citation

Reach, G. "[Artificial and Bioartificial Pancreas for the Treatment of Diabetes Mellitus]." Diabete & Metabolisme, vol. 20, no. 2 Pt 2, 1994, pp. 183-93.
Reach G. [Artificial and bioartificial pancreas for the treatment of diabetes mellitus]. Diabete Metab. 1994;20(2 Pt 2):183-93.
Reach, G. (1994). [Artificial and bioartificial pancreas for the treatment of diabetes mellitus]. Diabete & Metabolisme, 20(2 Pt 2), 183-93.
Reach G. [Artificial and Bioartificial Pancreas for the Treatment of Diabetes Mellitus]. Diabete Metab. 1994;20(2 Pt 2):183-93. PubMed PMID: 8001705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Artificial and bioartificial pancreas for the treatment of diabetes mellitus]. A1 - Reach,G, PY - 1994/1/1/pubmed PY - 2000/3/11/medline PY - 1994/1/1/entrez SP - 183 EP - 93 JF - Diabete & metabolisme JO - Diabete Metab VL - 20 IS - 2 Pt 2 N2 - The development of an artificial pancreas, a system in which insulin delivery would be regulated continuously by concomitant glucose levels, has been for a long time considered as a dream by diabetologists and diabetic patients. Two approaches are possible. The first one, electromechanical, consists of a glucose sensor, a computer and an insulin pump. Its development may be hindered by the inadequate biocompatibility of the glucose sensor. This led to consider at first the use of a disposable glucose sensor as part of a continuous glucose monitoring system. The second approach aims at developing a bioartificial pancreas, in which isolated islets of Langerhans would be protected against immune rejection by an artificial membrane permeable to glucose and insulin but not so to factors responsible for immune rejection. Thus, it may become possible to transplant a large number of patients before the onset of diabetic complications with xenogeneic islets, without need for any immunosuppression. Promises and obstacles of these two approaches are described herein. SN - 0338-1684 UR - https://www.unboundmedicine.com/medline/citation/8001705/[Artificial_and_bioartificial_pancreas_for_the_treatment_of_diabetes_mellitus]_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -