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Increase in thiobarbituric acid-reactive substances and vascular complications in type 2 diabetes mellitus.
Diabete Metab. 1994 May-Jun; 20(3):258-64.DM

Abstract

Lipid peroxidation was assessed by measuring the concentrations of thiobarbituric acid-reactive substances in plasma from 204 Type 2 diabetic patients, relative to 107 controls. The concentrations obtained in diabetic patients (3.08 +/- 0.37 mumol/l) were significantly higher than in controls (2.80 +/- 0.34 mumol/l) (p < 0.0001). Values were also significantly increased in patients with macroangiopathy and/or microangiopathy (3.17 +/- 0.41 mumol/l), relative to patients void of vascular complications (2.92 +/- 0.34 mumol/l) (p < 0.001). Elevated concentrations were independent of the type of vascular complication and their possible associations. In patients without vascular affection, thiobarbituric acid-reactive substances were in significantly higher concentrations in hypertensive (3.07 +/- 0.36 mumol/l) than in normotensive (2.87 +/- 0.29 mumol/l) (p < 0.01) patients. There was a correlation between these values and those of total cholesterol (r = 0.46, p < 0.0001) and triglyceride (r = 0.45, p < 0.0001). Statistical analysis by multivariate logistical regression revealed that among the independent factors (TBARS, APO A1, hypertension, age), thiobarbituric acid-reactive substances constituted the parameter most strongly linked to the existence of vascular complications. This study has evidenced a lipid peroxidation disorder in non insulin- dependent diabetes mellitus, more marked in patients with vascular affection. Thiobarbituric acid-reactive substances appear to be an independent marker of vascular complications in Type 2 diabetes.

Authors+Show Affiliations

Laboratoire de Biochimie Médicale A., Hôpital Sud, Rennes.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

8001713

Citation

Gallou, G, et al. "Increase in Thiobarbituric Acid-reactive Substances and Vascular Complications in Type 2 Diabetes Mellitus." Diabete & Metabolisme, vol. 20, no. 3, 1994, pp. 258-64.
Gallou G, Ruelland A, Campion L, et al. Increase in thiobarbituric acid-reactive substances and vascular complications in type 2 diabetes mellitus. Diabete Metab. 1994;20(3):258-64.
Gallou, G., Ruelland, A., Campion, L., Maugendre, D., Le Moullec, N., Legras, B., Allannic, H., & Cloarec, L. (1994). Increase in thiobarbituric acid-reactive substances and vascular complications in type 2 diabetes mellitus. Diabete & Metabolisme, 20(3), 258-64.
Gallou G, et al. Increase in Thiobarbituric Acid-reactive Substances and Vascular Complications in Type 2 Diabetes Mellitus. Diabete Metab. 1994 May-Jun;20(3):258-64. PubMed PMID: 8001713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increase in thiobarbituric acid-reactive substances and vascular complications in type 2 diabetes mellitus. AU - Gallou,G, AU - Ruelland,A, AU - Campion,L, AU - Maugendre,D, AU - Le Moullec,N, AU - Legras,B, AU - Allannic,H, AU - Cloarec,L, PY - 1994/5/1/pubmed PY - 2000/3/11/medline PY - 1994/5/1/entrez SP - 258 EP - 64 JF - Diabete & metabolisme JO - Diabete Metab VL - 20 IS - 3 N2 - Lipid peroxidation was assessed by measuring the concentrations of thiobarbituric acid-reactive substances in plasma from 204 Type 2 diabetic patients, relative to 107 controls. The concentrations obtained in diabetic patients (3.08 +/- 0.37 mumol/l) were significantly higher than in controls (2.80 +/- 0.34 mumol/l) (p < 0.0001). Values were also significantly increased in patients with macroangiopathy and/or microangiopathy (3.17 +/- 0.41 mumol/l), relative to patients void of vascular complications (2.92 +/- 0.34 mumol/l) (p < 0.001). Elevated concentrations were independent of the type of vascular complication and their possible associations. In patients without vascular affection, thiobarbituric acid-reactive substances were in significantly higher concentrations in hypertensive (3.07 +/- 0.36 mumol/l) than in normotensive (2.87 +/- 0.29 mumol/l) (p < 0.01) patients. There was a correlation between these values and those of total cholesterol (r = 0.46, p < 0.0001) and triglyceride (r = 0.45, p < 0.0001). Statistical analysis by multivariate logistical regression revealed that among the independent factors (TBARS, APO A1, hypertension, age), thiobarbituric acid-reactive substances constituted the parameter most strongly linked to the existence of vascular complications. This study has evidenced a lipid peroxidation disorder in non insulin- dependent diabetes mellitus, more marked in patients with vascular affection. Thiobarbituric acid-reactive substances appear to be an independent marker of vascular complications in Type 2 diabetes. SN - 0338-1684 UR - https://www.unboundmedicine.com/medline/citation/8001713/Increase_in_thiobarbituric_acid_reactive_substances_and_vascular_complications_in_type_2_diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/8215 DB - PRIME DP - Unbound Medicine ER -