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Cholesterol and violent behavior.
Arch Intern Med. 1994 Jun 27; 154(12):1317-21.AI

Abstract

Despite significant decreases [corrected] in the incidence of myocardial infarction, reduction of total mortality as a result of cholesterol-lowering programs has not been demonstrated. This puzzling outcome has led to several hypotheses linking cholesterol levels and mortality due to accidents, suicide, and homicide. We review the proposed explanations for increased mortality due to violent deaths. We discuss the available evidence and conclude that while there are some intriguing findings based on the well-established relationship between violent behavior and serotonin activity, the necessary link between cholesterol, serotonin, and violence has not been demonstrated. The complexity of the observed violent behaviors and their multiple determinants defies a simple explanation at the present time.

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Authors+Show Affiliations

Santiago JM
Department of Psychiatry, University of Arizona College of Medicine, Tucson.
Dalen JE
No affiliation info available

MeSH

AccidentsAnticholesteremic AgentsCardiovascular DiseasesCause of DeathCholesterolHumansMortalitySerotoninSuicideViolence

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8002683

Citation

Santiago, J M., and J E. Dalen. "Cholesterol and Violent Behavior." Archives of Internal Medicine, vol. 154, no. 12, 1994, pp. 1317-21.
Santiago JM, Dalen JE. Cholesterol and violent behavior. Arch Intern Med. 1994;154(12):1317-21.
Santiago, J. M., & Dalen, J. E. (1994). Cholesterol and violent behavior. Archives of Internal Medicine, 154(12), 1317-21.
Santiago JM, Dalen JE. Cholesterol and Violent Behavior. Arch Intern Med. 1994 Jun 27;154(12):1317-21. PubMed PMID: 8002683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholesterol and violent behavior. AU - Santiago,J M, AU - Dalen,J E, PY - 1994/6/27/pubmed PY - 1994/6/27/medline PY - 1994/6/27/entrez SP - 1317 EP - 21 JF - Archives of internal medicine JO - Arch Intern Med VL - 154 IS - 12 N2 - Despite significant decreases [corrected] in the incidence of myocardial infarction, reduction of total mortality as a result of cholesterol-lowering programs has not been demonstrated. This puzzling outcome has led to several hypotheses linking cholesterol levels and mortality due to accidents, suicide, and homicide. We review the proposed explanations for increased mortality due to violent deaths. We discuss the available evidence and conclude that while there are some intriguing findings based on the well-established relationship between violent behavior and serotonin activity, the necessary link between cholesterol, serotonin, and violence has not been demonstrated. The complexity of the observed violent behaviors and their multiple determinants defies a simple explanation at the present time. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/8002683/Cholesterol_and_violent_behavior_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/154/pg/1317 DB - PRIME DP - Unbound Medicine ER -