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Usefulness of serum ferritin levels in the assessment of iron status in non-pregnant Zairean women of childbearing age.
J Trop Med Hyg. 1994 Jun; 97(3):171-9.JT

Abstract

We studied the usefulness of serum ferritin for the assessment of iron deficiency (ID) or ID anaemia (IDA) of 186 lactating and 27 non-lactating Zairean women (15-45 years old). Haemoglobin (Hb), serum iron (SI), total iron binding capacity (TIBC), and transferrin saturation (TS) were also measured. Participants were recruited in rural Bas-Zaire State in the summers of 1986 and 1989. Serum ferritin ranged from 10 to 360 micrograms l-1 (median 62 micrograms l-1) in lactating women and from 14.2 to 120 micrograms l-1 (median 40 micrograms l-1) in non-lactating women. While mean levels of serum ferritin and TS were within the normal range in both groups of women, those of Hb were below normal (< 12 g dl-1), partly due to inflammation. The prevalence of anaemia was 66% in lactating women and 70% in non-lactating women, and did not change with time. It was higher in women with inflammation than in those without inflammation. Although ID (ferritin < 12 micrograms l-1) was almost absent, after raising the cut-off point of ferritin to 50 micrograms l-1 in women with inflammation, it was present in 28.8% of lactating women and 52% of non-lactating women. While the prevalence of ID assessed by serum ferritin was significantly higher in lactating women studied in 1989 (40.5%) than in those studied in 1986 (13.5%), it was similar in both groups of non-lactating women. ID defined by TS < 16% was present in 41% of lactating women and 21% of non-lactating women. In the presence as well as absence of inflammation, the use of TS identified a higher percentage of lactating women with either ID or IDA than did the use of serum ferritin. We conclude that, in the studied population, unless inflammation is taken into consideration, serum ferritin has a limited value in the diagnosis of ID.

Authors+Show Affiliations

Kuvibidila S
Department of Pediatrics, Louisiana State University, School of Medicine, New Orleans.
Yu L
No affiliation info available
Warrier RP
No affiliation info available
Ode D
No affiliation info available
Mbele V
No affiliation info available

MeSH

AdolescentAdultAnalysis of VarianceAnemia, HypochromicC-Reactive ProteinCross-Sectional StudiesDemocratic Republic of the CongoFemaleFerritinsHemoglobinsHumansInflammationIronLactationOrosomucoidPrevalenceTransferrin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8007058

Citation

Kuvibidila, S, et al. "Usefulness of Serum Ferritin Levels in the Assessment of Iron Status in Non-pregnant Zairean Women of Childbearing Age." The Journal of Tropical Medicine and Hygiene, vol. 97, no. 3, 1994, pp. 171-9.
Kuvibidila S, Yu L, Warrier RP, et al. Usefulness of serum ferritin levels in the assessment of iron status in non-pregnant Zairean women of childbearing age. J Trop Med Hyg. 1994;97(3):171-9.
Kuvibidila, S., Yu, L., Warrier, R. P., Ode, D., & Mbele, V. (1994). Usefulness of serum ferritin levels in the assessment of iron status in non-pregnant Zairean women of childbearing age. The Journal of Tropical Medicine and Hygiene, 97(3), 171-9.
Kuvibidila S, et al. Usefulness of Serum Ferritin Levels in the Assessment of Iron Status in Non-pregnant Zairean Women of Childbearing Age. J Trop Med Hyg. 1994;97(3):171-9. PubMed PMID: 8007058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of serum ferritin levels in the assessment of iron status in non-pregnant Zairean women of childbearing age. AU - Kuvibidila,S, AU - Yu,L, AU - Warrier,R P, AU - Ode,D, AU - Mbele,V, PY - 1994/6/1/pubmed PY - 1994/6/1/medline PY - 1994/6/1/entrez KW - Africa KW - Africa South Of The Sahara KW - Anemia--women KW - Biology KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Examinations And Diagnoses KW - French Speaking Africa KW - Hematologic Tests KW - Hematological Effects KW - Hemic System KW - Hemoglobin Level KW - Laboratory Examinations And Diagnoses KW - Laboratory Procedures KW - Lactation KW - Maternal Physiology KW - Middle Africa KW - Physiology KW - Population KW - Population Characteristics KW - Research Report KW - Rural Population--women KW - Serum Iron Level KW - Serum Protein Effects KW - Serum Total Iron Binding Capacity KW - Zaire SP - 171 EP - 9 JF - The Journal of tropical medicine and hygiene JO - J Trop Med Hyg VL - 97 IS - 3 N2 - We studied the usefulness of serum ferritin for the assessment of iron deficiency (ID) or ID anaemia (IDA) of 186 lactating and 27 non-lactating Zairean women (15-45 years old). Haemoglobin (Hb), serum iron (SI), total iron binding capacity (TIBC), and transferrin saturation (TS) were also measured. Participants were recruited in rural Bas-Zaire State in the summers of 1986 and 1989. Serum ferritin ranged from 10 to 360 micrograms l-1 (median 62 micrograms l-1) in lactating women and from 14.2 to 120 micrograms l-1 (median 40 micrograms l-1) in non-lactating women. While mean levels of serum ferritin and TS were within the normal range in both groups of women, those of Hb were below normal (< 12 g dl-1), partly due to inflammation. The prevalence of anaemia was 66% in lactating women and 70% in non-lactating women, and did not change with time. It was higher in women with inflammation than in those without inflammation. Although ID (ferritin < 12 micrograms l-1) was almost absent, after raising the cut-off point of ferritin to 50 micrograms l-1 in women with inflammation, it was present in 28.8% of lactating women and 52% of non-lactating women. While the prevalence of ID assessed by serum ferritin was significantly higher in lactating women studied in 1989 (40.5%) than in those studied in 1986 (13.5%), it was similar in both groups of non-lactating women. ID defined by TS < 16% was present in 41% of lactating women and 21% of non-lactating women. In the presence as well as absence of inflammation, the use of TS identified a higher percentage of lactating women with either ID or IDA than did the use of serum ferritin. We conclude that, in the studied population, unless inflammation is taken into consideration, serum ferritin has a limited value in the diagnosis of ID. SN - 0022-5304 UR - https://www.unboundmedicine.com/medline/citation/8007058/Usefulness_of_serum_ferritin_levels_in_the_assessment_of_iron_status_in_non_pregnant_Zairean_women_of_childbearing_age_ DB - PRIME DP - Unbound Medicine ER -