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Relationship between thromboxane B2 and 6-keto-prostaglandin F1 alpha in sepsis.
Res Commun Chem Pathol Pharmacol 1994; 83(3):297-302RC

Abstract

To examine the roles of thromboxane A2 and prostaglandin I2, which are arachidonic acid metabolites found in patients with sepsis, we measured the serum levels of their respective stable metabolites, thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) in 22 patients with sepsis. Results were analyzed in relation to patients' survival. The levels of both TXB2 and 6-keto-PGF1 alpha were significantly higher in patients who died than in those who survived, thus reflecting the severity of the patients' illness. There was a significant correlation between the levels of TXB2 and 6-keto-PGF1 alpha. These findings suggest that TXA2 and PGI2 are chemical mediators involved in the severity of clinical sepsis.

Authors+Show Affiliations

Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8008979

Citation

Nakae, H, et al. "Relationship Between Thromboxane B2 and 6-keto-prostaglandin F1 Alpha in Sepsis." Research Communications in Chemical Pathology and Pharmacology, vol. 83, no. 3, 1994, pp. 297-302.
Nakae H, Endo S, Inada K, et al. Relationship between thromboxane B2 and 6-keto-prostaglandin F1 alpha in sepsis. Res Commun Chem Pathol Pharmacol. 1994;83(3):297-302.
Nakae, H., Endo, S., Inada, K., Takakuwa, T., Kasai, T., & Yoshida, M. (1994). Relationship between thromboxane B2 and 6-keto-prostaglandin F1 alpha in sepsis. Research Communications in Chemical Pathology and Pharmacology, 83(3), pp. 297-302.
Nakae H, et al. Relationship Between Thromboxane B2 and 6-keto-prostaglandin F1 Alpha in Sepsis. Res Commun Chem Pathol Pharmacol. 1994;83(3):297-302. PubMed PMID: 8008979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between thromboxane B2 and 6-keto-prostaglandin F1 alpha in sepsis. AU - Nakae,H, AU - Endo,S, AU - Inada,K, AU - Takakuwa,T, AU - Kasai,T, AU - Yoshida,M, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 297 EP - 302 JF - Research communications in chemical pathology and pharmacology JO - Res. Commun. Chem. Pathol. Pharmacol. VL - 83 IS - 3 N2 - To examine the roles of thromboxane A2 and prostaglandin I2, which are arachidonic acid metabolites found in patients with sepsis, we measured the serum levels of their respective stable metabolites, thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) in 22 patients with sepsis. Results were analyzed in relation to patients' survival. The levels of both TXB2 and 6-keto-PGF1 alpha were significantly higher in patients who died than in those who survived, thus reflecting the severity of the patients' illness. There was a significant correlation between the levels of TXB2 and 6-keto-PGF1 alpha. These findings suggest that TXA2 and PGI2 are chemical mediators involved in the severity of clinical sepsis. SN - 0034-5164 UR - https://www.unboundmedicine.com/medline/citation/8008979/Relationship_between_thromboxane_B2_and_6_keto_prostaglandin_F1_alpha_in_sepsis_ DB - PRIME DP - Unbound Medicine ER -