Tags

Type your tag names separated by a space and hit enter

T cells from the peripheral blood of coeliac disease patients recognize gluten antigens when presented by HLA-DR, -DQ, or -DP molecules.
Scand J Immunol. 1994 Jun; 39(6):567-74.SJ

Abstract

Coeliac disease (CD) is a T-cell mediated immunological disease of the small intestine which is precipitated in susceptible individuals by ingestion of gluten. We recently reported that gliadin-specific T cells can be found in the small intestinal mucosa of CD patients, and that a preponderance of these T cells was restricted by the CD-associated DQ(alpha 1*0501,beta 1*0201) heterodimer. Here we report studies on whether the same is found for gliadin specific T cells in the peripheral blood of CD patients. T-cell responses towards gluten antigens in vitro were found for both most CD patients and healthy controls. Gluten-specific T-cell clones (TCC) were established from four CD patients. Although a large proportion of these TCC were restricted by DQ molecules, including the CD-associated DQ(alpha 1*0501,beta 1*0201) heterodimer, several were restricted instead by DR or DP molecules. Thus, gluten-derived peptides can be presented to T cells by several different HLA class-II molecules, and the preferential DQ(alpha 1*0501,beta 1*0201) restriction of gluten-specific T cells in the small intestinal mucosa of CD patients is less pronounced than for similar T cells in the peripheral blood.

Authors+Show Affiliations

Institute of Transplantation Immunology, National Hospital, Oslo, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8009173

Citation

Gjertsen, H A., et al. "T Cells From the Peripheral Blood of Coeliac Disease Patients Recognize Gluten Antigens when Presented By HLA-DR, -DQ, or -DP Molecules." Scandinavian Journal of Immunology, vol. 39, no. 6, 1994, pp. 567-74.
Gjertsen HA, Sollid LM, Ek J, et al. T cells from the peripheral blood of coeliac disease patients recognize gluten antigens when presented by HLA-DR, -DQ, or -DP molecules. Scand J Immunol. 1994;39(6):567-74.
Gjertsen, H. A., Sollid, L. M., Ek, J., Thorsby, E., & Lundin, K. E. (1994). T cells from the peripheral blood of coeliac disease patients recognize gluten antigens when presented by HLA-DR, -DQ, or -DP molecules. Scandinavian Journal of Immunology, 39(6), 567-74.
Gjertsen HA, et al. T Cells From the Peripheral Blood of Coeliac Disease Patients Recognize Gluten Antigens when Presented By HLA-DR, -DQ, or -DP Molecules. Scand J Immunol. 1994;39(6):567-74. PubMed PMID: 8009173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - T cells from the peripheral blood of coeliac disease patients recognize gluten antigens when presented by HLA-DR, -DQ, or -DP molecules. AU - Gjertsen,H A, AU - Sollid,L M, AU - Ek,J, AU - Thorsby,E, AU - Lundin,K E, PY - 1994/6/1/pubmed PY - 1994/6/1/medline PY - 1994/6/1/entrez SP - 567 EP - 74 JF - Scandinavian journal of immunology JO - Scand J Immunol VL - 39 IS - 6 N2 - Coeliac disease (CD) is a T-cell mediated immunological disease of the small intestine which is precipitated in susceptible individuals by ingestion of gluten. We recently reported that gliadin-specific T cells can be found in the small intestinal mucosa of CD patients, and that a preponderance of these T cells was restricted by the CD-associated DQ(alpha 1*0501,beta 1*0201) heterodimer. Here we report studies on whether the same is found for gliadin specific T cells in the peripheral blood of CD patients. T-cell responses towards gluten antigens in vitro were found for both most CD patients and healthy controls. Gluten-specific T-cell clones (TCC) were established from four CD patients. Although a large proportion of these TCC were restricted by DQ molecules, including the CD-associated DQ(alpha 1*0501,beta 1*0201) heterodimer, several were restricted instead by DR or DP molecules. Thus, gluten-derived peptides can be presented to T cells by several different HLA class-II molecules, and the preferential DQ(alpha 1*0501,beta 1*0201) restriction of gluten-specific T cells in the small intestinal mucosa of CD patients is less pronounced than for similar T cells in the peripheral blood. SN - 0300-9475 UR - https://www.unboundmedicine.com/medline/citation/8009173/T_cells_from_the_peripheral_blood_of_coeliac_disease_patients_recognize_gluten_antigens_when_presented_by_HLA_DR__DQ_or__DP_molecules_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-9475&date=1994&volume=39&issue=6&spage=567 DB - PRIME DP - Unbound Medicine ER -