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Adverse reactions to practolol: some observations on the possible relevence to immune mechanisms.

Abstract

HLA antigen frequencies were determined in patients who had suffered adverse reaction to the beta-adrenergic blocking agent, practolol. No statistically significant differences were observed between these patients and control groups. The latter were selected to include two separate groups, normal random healthy population controls, and controls who had taken practolol with no apparent adverse effects. Patients suffering from the very severe form of reaction, sclerosing peritonitis, were analysed separately from those with other lesion e.g. ocular symptoms, but did not show any significant differences. Altered HLA antigen frequencies were observed for those control patients whose primary diagnosis was hypertension but this was considered to be due to selection bias.

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  • Authors

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    Source

    Allergy 33:2 1978 Apr pg 71-5

    MeSH

    Epitopes
    Eye Diseases
    Gene Frequency
    Genes, MHC Class II
    HLA Antigens
    Humans
    Peritonitis
    Practolol
    Sclerosis

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    80139

    Citation

    Dick, H M., et al. "Adverse Reactions to Practolol: some Observations On the Possible Relevence to Immune Mechanisms." Allergy, vol. 33, no. 2, 1978, pp. 71-5.
    Dick HM, Wright P, Chapman CM, et al. Adverse reactions to practolol: some observations on the possible relevence to immune mechanisms. Allergy. 1978;33(2):71-5.
    Dick, H. M., Wright, P., Chapman, C. M., Zacharias, F. J., & Nicholls, J. T. (1978). Adverse reactions to practolol: some observations on the possible relevence to immune mechanisms. Allergy, 33(2), pp. 71-5.
    Dick HM, et al. Adverse Reactions to Practolol: some Observations On the Possible Relevence to Immune Mechanisms. Allergy. 1978;33(2):71-5. PubMed PMID: 80139.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adverse reactions to practolol: some observations on the possible relevence to immune mechanisms. AU - Dick,H M, AU - Wright,P, AU - Chapman,C M, AU - Zacharias,F J, AU - Nicholls,J T, PY - 1978/4/1/pubmed PY - 1978/4/1/medline PY - 1978/4/1/entrez SP - 71 EP - 5 JF - Allergy JO - Allergy VL - 33 IS - 2 N2 - HLA antigen frequencies were determined in patients who had suffered adverse reaction to the beta-adrenergic blocking agent, practolol. No statistically significant differences were observed between these patients and control groups. The latter were selected to include two separate groups, normal random healthy population controls, and controls who had taken practolol with no apparent adverse effects. Patients suffering from the very severe form of reaction, sclerosing peritonitis, were analysed separately from those with other lesion e.g. ocular symptoms, but did not show any significant differences. Altered HLA antigen frequencies were observed for those control patients whose primary diagnosis was hypertension but this was considered to be due to selection bias. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/80139/Adverse_reactions_to_practolol:_some_observations_on_the_possible_relevence_to_immune_mechanisms_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=1978&volume=33&issue=2&spage=71 DB - PRIME DP - Unbound Medicine ER -