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Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators.
N Engl J Med. 1994 Jul 28; 331(4):228-33.NEJM

Abstract

BACKGROUND

Fish contain n-3 polyunsaturated fatty acids, principally eicosapentaenoic acid and docosahexaenoic acid, which are known to interfere with the body's inflammatory response and may be of benefit in chronic inflammatory conditions.

METHODS

We studied the relation between the dietary intake of n-3 fatty acids and chronic obstructive pulmonary disease (COPD) in 8960 current or former smokers participating in a population-based study of atherosclerosis. Intake of fatty acids was estimated with a dietary questionnaire. The presence of COPD was assessed by a questionnaire on respiratory symptoms and by spirometry. Three case definitions of COPD were used: symptoms of chronic bronchitis (667 subjects), physician-diagnosed emphysema reported by the subject (185 subjects), and spirometrically detected COPD (197 subjects).

RESULTS

After control for pack-years of smoking, age, sex, race, height, weight, energy intake, and educational level, the combined intake of eicosapentaenoic acid and docosahexaenoic acid was inversely related to the risk of COPD in a quantity-dependent fashion. The adjusted odds ratio for the highest quartile of intake as compared with the lowest quartile was 0.66 for chronic bronchitis (95 percent confidence interval, 0.52 to 0.85; P < 0.001 for linear trend across the range of intake values), 0.31 for physician-diagnosed emphysema (95 percent confidence interval, 0.18 to 0.52; P for linear trend, 0.003), and 0.50 for spirometrically detected COPD (95 percent confidence interval, 0.32 to 0.79; P for linear trend, 0.007).

CONCLUSIONS

A high dietary intake of n-3 fatty acids may protect cigarette smokers against COPD.

Authors+Show Affiliations

Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8015569

Citation

Shahar, E, et al. "Dietary N-3 Polyunsaturated Fatty Acids and Smoking-related Chronic Obstructive Pulmonary Disease. Atherosclerosis Risk in Communities Study Investigators." The New England Journal of Medicine, vol. 331, no. 4, 1994, pp. 228-33.
Shahar E, Folsom AR, Melnick SL, et al. Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators. N Engl J Med. 1994;331(4):228-33.
Shahar, E., Folsom, A. R., Melnick, S. L., Tockman, M. S., Comstock, G. W., Gennaro, V., Higgins, M. W., Sorlie, P. D., Ko, W. J., & Szklo, M. (1994). Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators. The New England Journal of Medicine, 331(4), 228-33.
Shahar E, et al. Dietary N-3 Polyunsaturated Fatty Acids and Smoking-related Chronic Obstructive Pulmonary Disease. Atherosclerosis Risk in Communities Study Investigators. N Engl J Med. 1994 Jul 28;331(4):228-33. PubMed PMID: 8015569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators. AU - Shahar,E, AU - Folsom,A R, AU - Melnick,S L, AU - Tockman,M S, AU - Comstock,G W, AU - Gennaro,V, AU - Higgins,M W, AU - Sorlie,P D, AU - Ko,W J, AU - Szklo,M, PY - 1994/7/28/pubmed PY - 1994/7/28/medline PY - 1994/7/28/entrez SP - 228 EP - 33 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 331 IS - 4 N2 - BACKGROUND: Fish contain n-3 polyunsaturated fatty acids, principally eicosapentaenoic acid and docosahexaenoic acid, which are known to interfere with the body's inflammatory response and may be of benefit in chronic inflammatory conditions. METHODS: We studied the relation between the dietary intake of n-3 fatty acids and chronic obstructive pulmonary disease (COPD) in 8960 current or former smokers participating in a population-based study of atherosclerosis. Intake of fatty acids was estimated with a dietary questionnaire. The presence of COPD was assessed by a questionnaire on respiratory symptoms and by spirometry. Three case definitions of COPD were used: symptoms of chronic bronchitis (667 subjects), physician-diagnosed emphysema reported by the subject (185 subjects), and spirometrically detected COPD (197 subjects). RESULTS: After control for pack-years of smoking, age, sex, race, height, weight, energy intake, and educational level, the combined intake of eicosapentaenoic acid and docosahexaenoic acid was inversely related to the risk of COPD in a quantity-dependent fashion. The adjusted odds ratio for the highest quartile of intake as compared with the lowest quartile was 0.66 for chronic bronchitis (95 percent confidence interval, 0.52 to 0.85; P < 0.001 for linear trend across the range of intake values), 0.31 for physician-diagnosed emphysema (95 percent confidence interval, 0.18 to 0.52; P for linear trend, 0.003), and 0.50 for spirometrically detected COPD (95 percent confidence interval, 0.32 to 0.79; P for linear trend, 0.007). CONCLUSIONS: A high dietary intake of n-3 fatty acids may protect cigarette smokers against COPD. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/8015569/Dietary_n_3_polyunsaturated_fatty_acids_and_smoking_related_chronic_obstructive_pulmonary_disease__Atherosclerosis_Risk_in_Communities_Study_Investigators_ L2 - http://www.nejm.org/doi/full/10.1056/NEJM199407283310403?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -