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Antidiuretic hormone restores the endolymphatic longitudinal K+ gradient in the Brattleboro rat cochlea.
Pflugers Arch. 1994 Mar; 426(5):446-52.PA

Abstract

In the cochlea, endolymph is hyperosmotic to plasma and perilymph. To test the hypothesis that antidiuretic hormone is involved in the modulation of endolymph secretion, the electrochemical composition of cochlear fluids, endolymph and perilymph, was studied in three groups of anaesthetized rats: control Long Evans rats, homozygous Brattleboro rats that are genetically deprived of antidiuretic hormone, and Brattleboro rats that were treated with antidiuretic hormone (dDAVP, 0.5 microgram/100 g body weight/24 h during 8 days). Endolymph was sampled from the scala media at each turn of the cochlea and perilymph from the scala vestibuli. In Long Evans rats, the endocochlear potential, the endolymphatic K+ and Cl- concentrations decreased from base to apex of the cochlea as previously reported in guinea pigs and Sprague Dawley rats. In Brattleboro rats, the endocochlear potential and the Cl- concentration gradients were still present, whereas the K+ concentration gradient were still present, whereas the K+ concentration gradient was absent. This K+ gradient was restored by the administration of dDAVP, which increased the K+ concentration at the base of the cochlea. This work indicates that the K+ secretion in endolymph, and thus the osmolality, may be locally modulated by the antidiuretic hormone, probably via V2 receptors.

Authors+Show Affiliations

INSERM U.251, Faculté Xavier Bichat, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8015893

Citation

Julien, N, et al. "Antidiuretic Hormone Restores the Endolymphatic Longitudinal K+ Gradient in the Brattleboro Rat Cochlea." Pflugers Archiv : European Journal of Physiology, vol. 426, no. 5, 1994, pp. 446-52.
Julien N, Loiseau A, Sterkers O, et al. Antidiuretic hormone restores the endolymphatic longitudinal K+ gradient in the Brattleboro rat cochlea. Pflugers Arch. 1994;426(5):446-52.
Julien, N., Loiseau, A., Sterkers, O., Amiel, C., & Ferrary, E. (1994). Antidiuretic hormone restores the endolymphatic longitudinal K+ gradient in the Brattleboro rat cochlea. Pflugers Archiv : European Journal of Physiology, 426(5), 446-52.
Julien N, et al. Antidiuretic Hormone Restores the Endolymphatic Longitudinal K+ Gradient in the Brattleboro Rat Cochlea. Pflugers Arch. 1994;426(5):446-52. PubMed PMID: 8015893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiuretic hormone restores the endolymphatic longitudinal K+ gradient in the Brattleboro rat cochlea. AU - Julien,N, AU - Loiseau,A, AU - Sterkers,O, AU - Amiel,C, AU - Ferrary,E, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 446 EP - 52 JF - Pflugers Archiv : European journal of physiology JO - Pflugers Arch. VL - 426 IS - 5 N2 - In the cochlea, endolymph is hyperosmotic to plasma and perilymph. To test the hypothesis that antidiuretic hormone is involved in the modulation of endolymph secretion, the electrochemical composition of cochlear fluids, endolymph and perilymph, was studied in three groups of anaesthetized rats: control Long Evans rats, homozygous Brattleboro rats that are genetically deprived of antidiuretic hormone, and Brattleboro rats that were treated with antidiuretic hormone (dDAVP, 0.5 microgram/100 g body weight/24 h during 8 days). Endolymph was sampled from the scala media at each turn of the cochlea and perilymph from the scala vestibuli. In Long Evans rats, the endocochlear potential, the endolymphatic K+ and Cl- concentrations decreased from base to apex of the cochlea as previously reported in guinea pigs and Sprague Dawley rats. In Brattleboro rats, the endocochlear potential and the Cl- concentration gradients were still present, whereas the K+ concentration gradient were still present, whereas the K+ concentration gradient was absent. This K+ gradient was restored by the administration of dDAVP, which increased the K+ concentration at the base of the cochlea. This work indicates that the K+ secretion in endolymph, and thus the osmolality, may be locally modulated by the antidiuretic hormone, probably via V2 receptors. SN - 0031-6768 UR - https://www.unboundmedicine.com/medline/citation/8015893/Antidiuretic_hormone_restores_the_endolymphatic_longitudinal_K+_gradient_in_the_Brattleboro_rat_cochlea_ DB - PRIME DP - Unbound Medicine ER -