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[Differences in serum selenium concentration in probands and patients with colorectal neoplasms in Zagreb, Croatia].
Acta Med Austriaca 1994; 21(1):19-23AM

Abstract

Serum selenium concentration (scSe) (microgram/l) was comparatively measured in healthy persons (n = 202), patients with colorectal adenoma(s) (n = 44) and colorectal carcinoma (n = 48). In patients with adenoma(s) scSe (59.05 +/- 15) was significantly lower (p < 0.001) compared with scSe in the control group (66.8 +/- 14.43). Hyposelenemia was more pronounced in patients with multiple polyps (n = 11) than in patients with single adenoma (n = 33) (p < 0.05). Patients with colorectal carcinoma had also significant decrease in scSe (50.93 +/- 13.81) compared with the control group (p < 0.001 and with the adenoma patients (p < 0.001). According to the analysis of variance, highly significant differences were found among the cancer patients stratified in Dukes' stages A to D (p < 0.001), indicating a strong negative correlation between extension of cancer and hyposelenemia. Furthermore, hyposelenemia seemed to be more pronounced in the mucinous type of carcinoma than in adenocarcinoma (p = 0.056). This results indicate that hyposelenemia is strongly associated with colorectal neoplasia (including extension and severity of the disease) and that it may not only be a result but also one of tumorogenic factors. That means that selenium supplementation could be important in prevention or even adjuvant therapy of colorectal cancer.

Authors+Show Affiliations

Gastroenterologischen Abteilung der Inneren Klinik, Universitätsklinik, Rebro, Zagreb, Kroatien.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

8017164

Citation

Vucelic, B, et al. "[Differences in Serum Selenium Concentration in Probands and Patients With Colorectal Neoplasms in Zagreb, Croatia]." Acta Medica Austriaca, vol. 21, no. 1, 1994, pp. 19-23.
Vucelic B, Buljevac M, Romic Z, et al. [Differences in serum selenium concentration in probands and patients with colorectal neoplasms in Zagreb, Croatia]. Acta Med Austriaca. 1994;21(1):19-23.
Vucelic, B., Buljevac, M., Romic, Z., Milicic, D., Ostojic, R., & Krznaric, Z. (1994). [Differences in serum selenium concentration in probands and patients with colorectal neoplasms in Zagreb, Croatia]. Acta Medica Austriaca, 21(1), pp. 19-23.
Vucelic B, et al. [Differences in Serum Selenium Concentration in Probands and Patients With Colorectal Neoplasms in Zagreb, Croatia]. Acta Med Austriaca. 1994;21(1):19-23. PubMed PMID: 8017164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Differences in serum selenium concentration in probands and patients with colorectal neoplasms in Zagreb, Croatia]. AU - Vucelic,B, AU - Buljevac,M, AU - Romic,Z, AU - Milicic,D, AU - Ostojic,R, AU - Krznaric,Z, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 19 EP - 23 JF - Acta medica Austriaca JO - Acta Med. Austriaca VL - 21 IS - 1 N2 - Serum selenium concentration (scSe) (microgram/l) was comparatively measured in healthy persons (n = 202), patients with colorectal adenoma(s) (n = 44) and colorectal carcinoma (n = 48). In patients with adenoma(s) scSe (59.05 +/- 15) was significantly lower (p < 0.001) compared with scSe in the control group (66.8 +/- 14.43). Hyposelenemia was more pronounced in patients with multiple polyps (n = 11) than in patients with single adenoma (n = 33) (p < 0.05). Patients with colorectal carcinoma had also significant decrease in scSe (50.93 +/- 13.81) compared with the control group (p < 0.001 and with the adenoma patients (p < 0.001). According to the analysis of variance, highly significant differences were found among the cancer patients stratified in Dukes' stages A to D (p < 0.001), indicating a strong negative correlation between extension of cancer and hyposelenemia. Furthermore, hyposelenemia seemed to be more pronounced in the mucinous type of carcinoma than in adenocarcinoma (p = 0.056). This results indicate that hyposelenemia is strongly associated with colorectal neoplasia (including extension and severity of the disease) and that it may not only be a result but also one of tumorogenic factors. That means that selenium supplementation could be important in prevention or even adjuvant therapy of colorectal cancer. SN - 0303-8173 UR - https://www.unboundmedicine.com/medline/citation/8017164/[Differences_in_serum_selenium_concentration_in_probands_and_patients_with_colorectal_neoplasms_in_Zagreb_Croatia]_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0303-8173&amp;date=1994&amp;volume=21&amp;issue=1&amp;spage=19 DB - PRIME DP - Unbound Medicine ER -