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Plasma selenium and glutathione peroxidase activities in individuals living in the Veneto region of Italy.
J Trace Elem Electrolytes Health Dis. 1993 Dec; 7(4):242-4.JT

Abstract

In order to assess the Se status in individuals living in the Veneto region, a series of related measurements was performed. These included plasma selenium by PIXE and glutathione-peroxidase (GSH-Px) activities in plasma, red blood cells and platelets. Individuals were either normals or people suffering from various liver diseases. Moreover, an oral supplement of sodium selenite was given to 13 patients suffering from stable chronic renal failure (CRF) in parallel to 26 normals: data on plasma GSH-Px and on serum creatinine and creatinine clearance were collected either before or after supplementation. Results were in support of a relatively low selenium status: mean +/- SD plasma Se values of normals (0.82 +/- 0.17mumol/L, n = 82) were comparable to data observed in European regions where Se deficiency was already known. Even lower values were observed in those with liver diseases. Among enzyme activities, the distribution of the data of platelet GSH-Px was in further support of low Se status in the evaluated individuals. After Se supplementation, both normals and CRF patients showed a significant increase in the creatinine clearance, reflecting an improvement of the glomerular filtration rate. We suggest that more extensive surveys of the Se status should be carried out in Italy; moreover, Se supplementation may be advisable in individuals affected with moderate impairment of renal function.

Authors+Show Affiliations

Laboratorio di Chimica Clinica C.O.C. Valeggio s.M. Università di Verona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8019157

Citation

Bellisola, G, et al. "Plasma Selenium and Glutathione Peroxidase Activities in Individuals Living in the Veneto Region of Italy." Journal of Trace Elements and Electrolytes in Health and Disease, vol. 7, no. 4, 1993, pp. 242-4.
Bellisola G, Perona G, Galassini S, et al. Plasma selenium and glutathione peroxidase activities in individuals living in the Veneto region of Italy. J Trace Elem Electrolytes Health Dis. 1993;7(4):242-4.
Bellisola, G., Perona, G., Galassini, S., Moschini, G., & Guidi, G. C. (1993). Plasma selenium and glutathione peroxidase activities in individuals living in the Veneto region of Italy. Journal of Trace Elements and Electrolytes in Health and Disease, 7(4), 242-4.
Bellisola G, et al. Plasma Selenium and Glutathione Peroxidase Activities in Individuals Living in the Veneto Region of Italy. J Trace Elem Electrolytes Health Dis. 1993;7(4):242-4. PubMed PMID: 8019157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma selenium and glutathione peroxidase activities in individuals living in the Veneto region of Italy. AU - Bellisola,G, AU - Perona,G, AU - Galassini,S, AU - Moschini,G, AU - Guidi,G C, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 242 EP - 4 JF - Journal of trace elements and electrolytes in health and disease JO - J Trace Elem Electrolytes Health Dis VL - 7 IS - 4 N2 - In order to assess the Se status in individuals living in the Veneto region, a series of related measurements was performed. These included plasma selenium by PIXE and glutathione-peroxidase (GSH-Px) activities in plasma, red blood cells and platelets. Individuals were either normals or people suffering from various liver diseases. Moreover, an oral supplement of sodium selenite was given to 13 patients suffering from stable chronic renal failure (CRF) in parallel to 26 normals: data on plasma GSH-Px and on serum creatinine and creatinine clearance were collected either before or after supplementation. Results were in support of a relatively low selenium status: mean +/- SD plasma Se values of normals (0.82 +/- 0.17mumol/L, n = 82) were comparable to data observed in European regions where Se deficiency was already known. Even lower values were observed in those with liver diseases. Among enzyme activities, the distribution of the data of platelet GSH-Px was in further support of low Se status in the evaluated individuals. After Se supplementation, both normals and CRF patients showed a significant increase in the creatinine clearance, reflecting an improvement of the glomerular filtration rate. We suggest that more extensive surveys of the Se status should be carried out in Italy; moreover, Se supplementation may be advisable in individuals affected with moderate impairment of renal function. SN - 0931-2838 UR - https://www.unboundmedicine.com/medline/citation/8019157/Plasma_selenium_and_glutathione_peroxidase_activities_in_individuals_living_in_the_Veneto_region_of_Italy_ L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -