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Further studies on motor and sensory nerve regeneration in mice with delayed Wallerian degeneration.
Eur J Neurosci. 1994 Mar 01; 6(3):420-8.EJ

Abstract

The axons of both peripheral and central neurons in C57BL/Wlds (C57BL/Ola) mice are unique among mammals in degenerating extremely slowly after axotomy. Motor and sensory axons attempting to regenerate are thus confronted with an intact distal nerve stump rather than axon- and myelin-free Schwann cell-filled endoneurial tubes. Surprisingly, however, motor axons in the sciatic nerve innervating the soleus muscle regenerate rapidly, and there is evidence that they may use Schwann cells associated with unmyelinated fibres as a pathway. If this is so, motor axon regeneration might be impaired in C57BL/Wlds mice in the phrenic nerve, which has very few unmyelinated fibres. We found that as long as the myelinated axons in the distal stump of the phrenic nerve remained intact (up to 10 days), regeneration of motor axons did not occur, in spite of vigorous production of sprouts at the crush site. In contrast to motor axons, myelinated sensory axons regenerate very poorly in C57BL/Wlds mice, even in the presence of unmyelinated axons. We showed that this was also due to adverse local conditions confronting nerve sprouts, for the dorsal root ganglion cell bodies responded normally to injury with a rapid induction of Jun protein-like immunoreactivity and when the saphenous nerve was forced to degenerate more rapidly by multiple crush lesions sensory axons regrew much more successfully. The findings show that motor and sensory axons in C57BL/Wlds mice, although very atypical in the way that they degenerate, are able to regenerate normally but only in an appropriate environment.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

University Laboratory of Physiology, Oxford, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8019679

Citation

Brown, M C., et al. "Further Studies On Motor and Sensory Nerve Regeneration in Mice With Delayed Wallerian Degeneration." The European Journal of Neuroscience, vol. 6, no. 3, 1994, pp. 420-8.
Brown MC, Perry VH, Hunt SP, et al. Further studies on motor and sensory nerve regeneration in mice with delayed Wallerian degeneration. Eur J Neurosci. 1994;6(3):420-8.
Brown, M. C., Perry, V. H., Hunt, S. P., & Lapper, S. R. (1994). Further studies on motor and sensory nerve regeneration in mice with delayed Wallerian degeneration. The European Journal of Neuroscience, 6(3), 420-8.
Brown MC, et al. Further Studies On Motor and Sensory Nerve Regeneration in Mice With Delayed Wallerian Degeneration. Eur J Neurosci. 1994 Mar 1;6(3):420-8. PubMed PMID: 8019679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further studies on motor and sensory nerve regeneration in mice with delayed Wallerian degeneration. AU - Brown,M C, AU - Perry,V H, AU - Hunt,S P, AU - Lapper,S R, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 420 EP - 8 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 6 IS - 3 N2 - The axons of both peripheral and central neurons in C57BL/Wlds (C57BL/Ola) mice are unique among mammals in degenerating extremely slowly after axotomy. Motor and sensory axons attempting to regenerate are thus confronted with an intact distal nerve stump rather than axon- and myelin-free Schwann cell-filled endoneurial tubes. Surprisingly, however, motor axons in the sciatic nerve innervating the soleus muscle regenerate rapidly, and there is evidence that they may use Schwann cells associated with unmyelinated fibres as a pathway. If this is so, motor axon regeneration might be impaired in C57BL/Wlds mice in the phrenic nerve, which has very few unmyelinated fibres. We found that as long as the myelinated axons in the distal stump of the phrenic nerve remained intact (up to 10 days), regeneration of motor axons did not occur, in spite of vigorous production of sprouts at the crush site. In contrast to motor axons, myelinated sensory axons regenerate very poorly in C57BL/Wlds mice, even in the presence of unmyelinated axons. We showed that this was also due to adverse local conditions confronting nerve sprouts, for the dorsal root ganglion cell bodies responded normally to injury with a rapid induction of Jun protein-like immunoreactivity and when the saphenous nerve was forced to degenerate more rapidly by multiple crush lesions sensory axons regrew much more successfully. The findings show that motor and sensory axons in C57BL/Wlds mice, although very atypical in the way that they degenerate, are able to regenerate normally but only in an appropriate environment.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/8019679/Further_studies_on_motor_and_sensory_nerve_regeneration_in_mice_with_delayed_Wallerian_degeneration_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=1994&volume=6&issue=3&spage=420 DB - PRIME DP - Unbound Medicine ER -