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Endoscopic sclerotherapy in Zimbabwe.
Cent Afr J Med. 1993 Sep; 39(9):177-80.CA

Abstract

Fifty consecutive patients presenting with upper gastrointestinal haemorrhage caused by oesophageal varices were subjected to endoscopic sclerotherapy during the period April 1989 to December 1991. Portal hypertension was caused by alcoholic liver cirrhosis in 22 (44pc), Hepatitis B induced liver cirrhosis in seven (14pc), cryptogenic liver cirrhosis in three (six pc), bilharzial portal fibrosis in 17 (34pc) and extrahepatic portal obstruction in one (two pc). Acute bleeding was controlled in 12 out of 13 patients, five of whom with a fresh bleed and eight who rebled while on the endoscopic sclerotherapy regimen. All patients were treated on a weekly sclerotherapy regimen. Reduction in variceal size of two or more grades was achieved in all 30 patients who had completed at least four or more endoscopic sclerotherapy courses with total eradication of varices in 27 (90pc). Three patients died. All deaths were caused by progressive hepatic encephalopathy. Complications usually seen were retrosternal pain, fever, dysphagia and oesophageal ulceration. There were no fatal complications. The study shows that endoscopic sclerotherapy is effective not only in controlling acute bleeding but also in preventing rebleeding. We recommend a weekly schedule for the early eradication of varices.

Authors+Show Affiliations

Department of Medicine, University of Zimbabwe, Avondale Harare.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8020085

Citation

Kiire, C F., et al. "Endoscopic Sclerotherapy in Zimbabwe." The Central African Journal of Medicine, vol. 39, no. 9, 1993, pp. 177-80.
Kiire CF, Gangaidzo IT, Sitima J, et al. Endoscopic sclerotherapy in Zimbabwe. Cent Afr J Med. 1993;39(9):177-80.
Kiire, C. F., Gangaidzo, I. T., Sitima, J., & Ndemera, B. (1993). Endoscopic sclerotherapy in Zimbabwe. The Central African Journal of Medicine, 39(9), 177-80.
Kiire CF, et al. Endoscopic Sclerotherapy in Zimbabwe. Cent Afr J Med. 1993;39(9):177-80. PubMed PMID: 8020085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endoscopic sclerotherapy in Zimbabwe. AU - Kiire,C F, AU - Gangaidzo,I T, AU - Sitima,J, AU - Ndemera,B, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 177 EP - 80 JF - The Central African journal of medicine JO - Cent Afr J Med VL - 39 IS - 9 N2 - Fifty consecutive patients presenting with upper gastrointestinal haemorrhage caused by oesophageal varices were subjected to endoscopic sclerotherapy during the period April 1989 to December 1991. Portal hypertension was caused by alcoholic liver cirrhosis in 22 (44pc), Hepatitis B induced liver cirrhosis in seven (14pc), cryptogenic liver cirrhosis in three (six pc), bilharzial portal fibrosis in 17 (34pc) and extrahepatic portal obstruction in one (two pc). Acute bleeding was controlled in 12 out of 13 patients, five of whom with a fresh bleed and eight who rebled while on the endoscopic sclerotherapy regimen. All patients were treated on a weekly sclerotherapy regimen. Reduction in variceal size of two or more grades was achieved in all 30 patients who had completed at least four or more endoscopic sclerotherapy courses with total eradication of varices in 27 (90pc). Three patients died. All deaths were caused by progressive hepatic encephalopathy. Complications usually seen were retrosternal pain, fever, dysphagia and oesophageal ulceration. There were no fatal complications. The study shows that endoscopic sclerotherapy is effective not only in controlling acute bleeding but also in preventing rebleeding. We recommend a weekly schedule for the early eradication of varices. SN - 0008-9176 UR - https://www.unboundmedicine.com/medline/citation/8020085/Endoscopic_sclerotherapy_in_Zimbabwe_ L2 - https://medlineplus.gov/gastrointestinalbleeding.html DB - PRIME DP - Unbound Medicine ER -