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[HELLP syndrome].
Zentralbl Gynakol. 1994; 116(4):195-201.ZG

Abstract

The HELLP syndrome is a severe and life-threatening complication of preeclampsia with typical laboratory findings. The frequency of the disease is 1 to 150-300 live births in perinatal centers. The median gestational age at presentation is 34 weeks, however, the disease may also develop during the early postpartum period. Right upper quadrant pain is the most striking clinical symptom; in up to 15% of cases neither hypertension nor proteinuria is present on admission. For the detection of hemolysis determination of haptoglobin levels is the most suitable method. Coagulation disorders are more pronounced in patients with the HELLP syndrome as compared to those with preeclampsia without the HELLP constellation, however the full-blown syndrome of disseminated intravascular coagulation (DIC) is not a leading symptom but the consequence of delayed diagnosis and/or therapy of the primary disease. The course of the HELLP syndrome is unpredictable. On the one hand, complete reversal of symptoms under conservative treatment have been reported in individual cases, on the other hand, rapid, therapy-resistant deterioration of the disease had been observed in the majority of patients accompanied by severe complications (e.g. liver rupture). As a consequence the mother and the newborn need intensive care, and these women should be delivered in an obstetric intensive care unit. The maternal mortality reported from the international literature is 3.3%, and the perinatal mortality 22.6%.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Rath W
Universitäts-Frauenklinik Göttingen.
Loos W
No affiliation info available
Kuhn W
No affiliation info available

MeSH

Critical CareDisseminated Intravascular CoagulationFemaleHELLP SyndromeHumansInfant, NewbornLiver Function TestsPlatelet CountPre-EclampsiaPregnancyPuerperal DisordersRecurrenceRisk Factors

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

8023604

Citation

Rath, W, et al. "[HELLP Syndrome]." Zentralblatt Fur Gynakologie, vol. 116, no. 4, 1994, pp. 195-201.
Rath W, Loos W, Kuhn W. [HELLP syndrome]. Zentralbl Gynakol. 1994;116(4):195-201.
Rath, W., Loos, W., & Kuhn, W. (1994). [HELLP syndrome]. Zentralblatt Fur Gynakologie, 116(4), 195-201.
Rath W, Loos W, Kuhn W. [HELLP Syndrome]. Zentralbl Gynakol. 1994;116(4):195-201. PubMed PMID: 8023604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [HELLP syndrome]. AU - Rath,W, AU - Loos,W, AU - Kuhn,W, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 195 EP - 201 JF - Zentralblatt fur Gynakologie JO - Zentralbl Gynakol VL - 116 IS - 4 N2 - The HELLP syndrome is a severe and life-threatening complication of preeclampsia with typical laboratory findings. The frequency of the disease is 1 to 150-300 live births in perinatal centers. The median gestational age at presentation is 34 weeks, however, the disease may also develop during the early postpartum period. Right upper quadrant pain is the most striking clinical symptom; in up to 15% of cases neither hypertension nor proteinuria is present on admission. For the detection of hemolysis determination of haptoglobin levels is the most suitable method. Coagulation disorders are more pronounced in patients with the HELLP syndrome as compared to those with preeclampsia without the HELLP constellation, however the full-blown syndrome of disseminated intravascular coagulation (DIC) is not a leading symptom but the consequence of delayed diagnosis and/or therapy of the primary disease. The course of the HELLP syndrome is unpredictable. On the one hand, complete reversal of symptoms under conservative treatment have been reported in individual cases, on the other hand, rapid, therapy-resistant deterioration of the disease had been observed in the majority of patients accompanied by severe complications (e.g. liver rupture). As a consequence the mother and the newborn need intensive care, and these women should be delivered in an obstetric intensive care unit. The maternal mortality reported from the international literature is 3.3%, and the perinatal mortality 22.6%.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0044-4197 UR - https://www.unboundmedicine.com/medline/citation/8023604/[HELLP_syndrome]_ L2 - http://www.diseaseinfosearch.org/result/3266 DB - PRIME DP - Unbound Medicine ER -