[Rheologic changes of blood in portal hypertension].Khirurgiia (Mosk). 1994 FebK
The role of hemorheologic disorders in the pathogenesis of portal hypertension in shown. Rheologic disorders are characteristic of both intrahepatic and extrahepatic forms of portal hypertension. It was found that the rate of hemolysis, disorders of the lipid composition and conformation of red cell proteins is reduced in cirrhosis of the liver complicated by portal hypertension. Changes in the portal system microvessels are attended by microcirculatory disorders which are aggravated by changes in the properties of the cell membrane caused by disorders of the blood physico-chemical properties. Purposeful correction of the hemorheologic disorders has a positive effect on the rheologic parameters only in 3-4 weeks. Postoperative complications occur most frequently on the 10th-14th day. A recurrence of acute hepatic insufficiency is also noted at this time in most patients after drainage of the thoracic duct in aggravation of blood rheology. Direct changes of blood rheology in the portal system were revealed, which is a manifestation of the continuously active mechanism of the syndrome which may cause thromboses and massive hemorrhage.