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[The clinical pharmacological profile of pinaverium bromide].
Minerva Med. 1994 Apr; 85(4):179-85.MM

Abstract

Pinaverium bromide is a locally acting spasmolytic agent of the digestive tract. Its mechanism of action relies upon inhibition of calcium ion entrance into smooth muscle cells (calcium-antagonist effect). In humans pinaverium facilitates gastric emptying and decreases intestinal transit time in patients with constipation. Pinaverium is very effective in improving symptoms of irritable bowel syndrome (abdominal pain, gas, diarrhea or constipation). In this respect the drug proved to be significantly superior to placebo, at least as effective as trimebutine and on the whole more active than otilonium and prifinium bromide, being always extremely well tolerated.

Authors+Show Affiliations

Servizio di Gastroenterologia, Istituto Scientifico Ospedale San Raffaele, Milano.

Pub Type(s)

English Abstract
Journal Article
Review

Language

ita

PubMed ID

8028745

Citation

Guslandi, M. "[The Clinical Pharmacological Profile of Pinaverium Bromide]." Minerva Medica, vol. 85, no. 4, 1994, pp. 179-85.
Guslandi M. [The clinical pharmacological profile of pinaverium bromide]. Minerva Med. 1994;85(4):179-85.
Guslandi, M. (1994). [The clinical pharmacological profile of pinaverium bromide]. Minerva Medica, 85(4), 179-85.
Guslandi M. [The Clinical Pharmacological Profile of Pinaverium Bromide]. Minerva Med. 1994;85(4):179-85. PubMed PMID: 8028745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The clinical pharmacological profile of pinaverium bromide]. A1 - Guslandi,M, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 179 EP - 85 JF - Minerva medica JO - Minerva Med VL - 85 IS - 4 N2 - Pinaverium bromide is a locally acting spasmolytic agent of the digestive tract. Its mechanism of action relies upon inhibition of calcium ion entrance into smooth muscle cells (calcium-antagonist effect). In humans pinaverium facilitates gastric emptying and decreases intestinal transit time in patients with constipation. Pinaverium is very effective in improving symptoms of irritable bowel syndrome (abdominal pain, gas, diarrhea or constipation). In this respect the drug proved to be significantly superior to placebo, at least as effective as trimebutine and on the whole more active than otilonium and prifinium bromide, being always extremely well tolerated. SN - 0026-4806 UR - https://www.unboundmedicine.com/medline/citation/8028745/[The_clinical_pharmacological_profile_of_pinaverium_bromide]_ DB - PRIME DP - Unbound Medicine ER -
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