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Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys.
Neurosci Lett. 1994 Feb 28; 168(1-2):251-3.NL

Abstract

The mechanism of abnormal iron accumulation in the substantia nigra (SN) pars compacta of patients with Parkinson's disease (PD) is unknown. To explore this question, we made a hemiparkinsonism model in monkeys by injecting 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the caudate or putamen on one side, and compared iron content in the SN and other basal ganglia structures by histochemistry. The injected side, especially the SN pars compacta, showed a marked increase in iron staining. Our study indicates that an injury to the nigrostriatal system by MPTP injection can induce iron accumulation in the SN.

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Authors+Show Affiliations

Mochizuki H
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Imai H
No affiliation info available
Endo K
No affiliation info available
Yokomizo K
No affiliation info available
Murata Y
No affiliation info available
Hattori N
No affiliation info available
Mizuno Y
No affiliation info available

MeSH

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBasal GangliaCaudate NucleusIronMPTP PoisoningMacaca fascicularisMaleMicroinjectionsParkinson Disease, SecondarySubstantia Nigra

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8028787

Citation

Mochizuki, H, et al. "Iron Accumulation in the Substantia Nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Hemiparkinsonian Monkeys." Neuroscience Letters, vol. 168, no. 1-2, 1994, pp. 251-3.
Mochizuki H, Imai H, Endo K, et al. Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys. Neurosci Lett. 1994;168(1-2):251-3.
Mochizuki, H., Imai, H., Endo, K., Yokomizo, K., Murata, Y., Hattori, N., & Mizuno, Y. (1994). Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys. Neuroscience Letters, 168(1-2), 251-3.
Mochizuki H, et al. Iron Accumulation in the Substantia Nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Hemiparkinsonian Monkeys. Neurosci Lett. 1994 Feb 28;168(1-2):251-3. PubMed PMID: 8028787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys. AU - Mochizuki,H, AU - Imai,H, AU - Endo,K, AU - Yokomizo,K, AU - Murata,Y, AU - Hattori,N, AU - Mizuno,Y, PY - 1994/2/28/pubmed PY - 1994/2/28/medline PY - 1994/2/28/entrez SP - 251 EP - 3 JF - Neuroscience letters JO - Neurosci Lett VL - 168 IS - 1-2 N2 - The mechanism of abnormal iron accumulation in the substantia nigra (SN) pars compacta of patients with Parkinson's disease (PD) is unknown. To explore this question, we made a hemiparkinsonism model in monkeys by injecting 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the caudate or putamen on one side, and compared iron content in the SN and other basal ganglia structures by histochemistry. The injected side, especially the SN pars compacta, showed a marked increase in iron staining. Our study indicates that an injury to the nigrostriatal system by MPTP injection can induce iron accumulation in the SN. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/8028787/Iron_accumulation_in_the_substantia_nigra_of_1_methyl_4_phenyl_1236_tetrahydropyridine__MPTP__induced_hemiparkinsonian_monkeys_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0304-3940(94)90462-6 DB - PRIME DP - Unbound Medicine ER -