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Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata.
Biochem Pharmacol. 1994 Jun 15; 47(12):2187-92.BP

Abstract

The antiviral activity of polysaccharide fractions obtained from water extracts of the red seaweed Nothogenia fastigiata was investigated. Fraction F6, corresponding to a sulphated xylomannan, was found to inhibit efficiently the replication of herpes simplex virus type 1 (HSV-1). Furthermore, F6 selectively inhibited the replication of several other enveloped viruses including herpes simplex virus type 2, human cytomegalovirus (HCMV), respiratory syncytial virus, influenza A and B virus, Junin and Tacaribe virus and simian immunodeficiency virus. F6 was only weakly active against human immunodeficiency virus type 1 and 2. The mode of action of F6 against HSV-1 and HCMV could be ascribed to an inhibitory effect on virus adsorption.

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Authors+Show Affiliations

Damonte E
Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Neyts J
No affiliation info available
Pujol CA
No affiliation info available
Snoeck R
No affiliation info available
Andrei G
No affiliation info available
Ikeda S
No affiliation info available
Witvrouw M
No affiliation info available
Reymen D
No affiliation info available
Haines H
No affiliation info available
Matulewicz MC
No affiliation info available

MeSH

Antiviral AgentsChemical FractionationHerpesvirus 1, HumanMicrobial Sensitivity TestsPolysaccharidesSeaweedVirus Replication

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8031312

Citation

Damonte, E, et al. "Antiviral Activity of a Sulphated Polysaccharide From the Red Seaweed Nothogenia Fastigiata." Biochemical Pharmacology, vol. 47, no. 12, 1994, pp. 2187-92.
Damonte E, Neyts J, Pujol CA, et al. Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata. Biochem Pharmacol. 1994;47(12):2187-92.
Damonte, E., Neyts, J., Pujol, C. A., Snoeck, R., Andrei, G., Ikeda, S., Witvrouw, M., Reymen, D., Haines, H., & Matulewicz, M. C. (1994). Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata. Biochemical Pharmacology, 47(12), 2187-92.
Damonte E, et al. Antiviral Activity of a Sulphated Polysaccharide From the Red Seaweed Nothogenia Fastigiata. Biochem Pharmacol. 1994 Jun 15;47(12):2187-92. PubMed PMID: 8031312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata. A1 - Damonte,E, AU - Neyts,J, AU - Pujol,C A, AU - Snoeck,R, AU - Andrei,G, AU - Ikeda,S, AU - Witvrouw,M, AU - Reymen,D, AU - Haines,H, AU - Matulewicz,M C, PY - 1994/6/15/pubmed PY - 1994/6/15/medline PY - 1994/6/15/entrez SP - 2187 EP - 92 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 47 IS - 12 N2 - The antiviral activity of polysaccharide fractions obtained from water extracts of the red seaweed Nothogenia fastigiata was investigated. Fraction F6, corresponding to a sulphated xylomannan, was found to inhibit efficiently the replication of herpes simplex virus type 1 (HSV-1). Furthermore, F6 selectively inhibited the replication of several other enveloped viruses including herpes simplex virus type 2, human cytomegalovirus (HCMV), respiratory syncytial virus, influenza A and B virus, Junin and Tacaribe virus and simian immunodeficiency virus. F6 was only weakly active against human immunodeficiency virus type 1 and 2. The mode of action of F6 against HSV-1 and HCMV could be ascribed to an inhibitory effect on virus adsorption. SN - 0006-2952 UR - https://www.unboundmedicine.com/medline/citation/8031312/Antiviral_activity_of_a_sulphated_polysaccharide_from_the_red_seaweed_Nothogenia_fastigiata_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-2952(94)90254-2 DB - PRIME DP - Unbound Medicine ER -