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Prevention of oral mucositis in patients treated with high-dose chemotherapy and bone marrow transplantation: a randomised controlled trial comparing two protocols of dental care.
Eur J Cancer B Oral Oncol 1994; 30B(2):93-7EJ

Abstract

Between February 1986 and November 1989, 166 patients who were candidates for a bone marrow transplantation entered a randomised controlled clinical trial to compare limited oral hygiene care (LIM) and intensive oral hygiene care (INT) in the prevention of mucositis. Randomisation was stratified on the initial oral status (good vs. bad IOS). Intensive oral hygiene care included an initial treatment of dental lesions and tooth and gum brushing during aplasia. Limited oral hygiene care excluded preventive dental treatment and gingival and tooth brushing. Mucositis was classified as absent, mild, moderate or severe, according to the clinical aspects of the different sites in the mouth and to two scales of pain evaluation. Of the 150 evaluable patients (75 in each group), 134 developed moderate/severe mucositis (64 in the INT group and 70 in the LIM group) (log-rank test P < 0.02). The superiority of intensive oral care was observed both in patients with and without total body irradiation (TBI) and in patients with a good or bad IOS; the observed risk of mucositis was reduced by 70% in each of these four subgroups. Duration of moderate/severe mucositis was, although not significantly, lower in the INT group (17 days, S.D. = 12) than in the LIM group (19 days, S.D. = 13). The median time of mucositis occurrence was 11 days in the INT group and 9 days in the LIM group. Contrary to a widespread belief, the percentage of documented septicaemia was not higher in patients who underwent intensive oral care. We conclude that, although statistically significant, the superiority of intensive oral hygiene care is not clinically impressive.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Dental Oncology Department, Institut Gustave Roussy, Villejuif, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8032307

Citation

Borowski, B, et al. "Prevention of Oral Mucositis in Patients Treated With High-dose Chemotherapy and Bone Marrow Transplantation: a Randomised Controlled Trial Comparing Two Protocols of Dental Care." European Journal of Cancer. Part B, Oral Oncology, vol. 30B, no. 2, 1994, pp. 93-7.
Borowski B, Benhamou E, Pico JL, et al. Prevention of oral mucositis in patients treated with high-dose chemotherapy and bone marrow transplantation: a randomised controlled trial comparing two protocols of dental care. Eur J Cancer, B, Oral Oncol. 1994;30B(2):93-7.
Borowski, B., Benhamou, E., Pico, J. L., Laplanche, A., Margainaud, J. P., & Hayat, M. (1994). Prevention of oral mucositis in patients treated with high-dose chemotherapy and bone marrow transplantation: a randomised controlled trial comparing two protocols of dental care. European Journal of Cancer. Part B, Oral Oncology, 30B(2), pp. 93-7.
Borowski B, et al. Prevention of Oral Mucositis in Patients Treated With High-dose Chemotherapy and Bone Marrow Transplantation: a Randomised Controlled Trial Comparing Two Protocols of Dental Care. Eur J Cancer, B, Oral Oncol. 1994;30B(2):93-7. PubMed PMID: 8032307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of oral mucositis in patients treated with high-dose chemotherapy and bone marrow transplantation: a randomised controlled trial comparing two protocols of dental care. AU - Borowski,B, AU - Benhamou,E, AU - Pico,J L, AU - Laplanche,A, AU - Margainaud,J P, AU - Hayat,M, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 93 EP - 7 JF - European journal of cancer. Part B, Oral oncology JO - Eur. J. Cancer, B, Oral Oncol. VL - 30B IS - 2 N2 - Between February 1986 and November 1989, 166 patients who were candidates for a bone marrow transplantation entered a randomised controlled clinical trial to compare limited oral hygiene care (LIM) and intensive oral hygiene care (INT) in the prevention of mucositis. Randomisation was stratified on the initial oral status (good vs. bad IOS). Intensive oral hygiene care included an initial treatment of dental lesions and tooth and gum brushing during aplasia. Limited oral hygiene care excluded preventive dental treatment and gingival and tooth brushing. Mucositis was classified as absent, mild, moderate or severe, according to the clinical aspects of the different sites in the mouth and to two scales of pain evaluation. Of the 150 evaluable patients (75 in each group), 134 developed moderate/severe mucositis (64 in the INT group and 70 in the LIM group) (log-rank test P < 0.02). The superiority of intensive oral care was observed both in patients with and without total body irradiation (TBI) and in patients with a good or bad IOS; the observed risk of mucositis was reduced by 70% in each of these four subgroups. Duration of moderate/severe mucositis was, although not significantly, lower in the INT group (17 days, S.D. = 12) than in the LIM group (19 days, S.D. = 13). The median time of mucositis occurrence was 11 days in the INT group and 9 days in the LIM group. Contrary to a widespread belief, the percentage of documented septicaemia was not higher in patients who underwent intensive oral care. We conclude that, although statistically significant, the superiority of intensive oral hygiene care is not clinically impressive.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0964-1955 UR - https://www.unboundmedicine.com/medline/citation/8032307/Prevention_of_oral_mucositis_in_patients_treated_with_high_dose_chemotherapy_and_bone_marrow_transplantation:_a_randomised_controlled_trial_comparing_two_protocols_of_dental_care_ L2 - http://www.diseaseinfosearch.org/result/7171 DB - PRIME DP - Unbound Medicine ER -