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Bilateral 6-OHDA lesions of the locus coeruleus impair associative olfactory learning in newborn rats.
Brain Res. 1994 Apr 18; 643(1-2):306-9.BR

Abstract

On postnatal day 4 (PN4) Wistar rat pups were anesthetized and received bilateral infusions of 6-OHDA into the locus coeruleus or received vehicle infusions. On PN6 pups were trained in a classical conditioning paradigm with intra-oral milk infusions as the UCS and citral odor as the CS. Pups were trained in either 'paired', 'odor-only', 'milk-only' or 'backward' (milk then odor) conditions. On PN7 acquisition of a learned odor preference to the CS was tested in a two-odor choice test. HPLC analysis showed that locus coeruleus lesions significantly reduced olfactory bulb NE content but had no effect on olfactory bulb DA or 5-HT levels compared to controls. Pups receiving locus coeruleus lesions did not differ in behavioral response patterns during training compared to their littermate, vehicle controls. However, locus coeruleus lesions impaired acquisition of conditioned odor preferences. These results suggest that NE output from the locus coeruleus is critical for early olfactory learning.

Authors+Show Affiliations

Department of Psychology, University of Oklahoma, Norman 73019.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8032925

Citation

Sullivan, R M., et al. "Bilateral 6-OHDA Lesions of the Locus Coeruleus Impair Associative Olfactory Learning in Newborn Rats." Brain Research, vol. 643, no. 1-2, 1994, pp. 306-9.
Sullivan RM, Wilson DA, Lemon C, et al. Bilateral 6-OHDA lesions of the locus coeruleus impair associative olfactory learning in newborn rats. Brain Res. 1994;643(1-2):306-9.
Sullivan, R. M., Wilson, D. A., Lemon, C., & Gerhardt, G. A. (1994). Bilateral 6-OHDA lesions of the locus coeruleus impair associative olfactory learning in newborn rats. Brain Research, 643(1-2), 306-9.
Sullivan RM, et al. Bilateral 6-OHDA Lesions of the Locus Coeruleus Impair Associative Olfactory Learning in Newborn Rats. Brain Res. 1994 Apr 18;643(1-2):306-9. PubMed PMID: 8032925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bilateral 6-OHDA lesions of the locus coeruleus impair associative olfactory learning in newborn rats. AU - Sullivan,R M, AU - Wilson,D A, AU - Lemon,C, AU - Gerhardt,G A, PY - 1994/4/18/pubmed PY - 1994/4/18/medline PY - 1994/4/18/entrez SP - 306 EP - 9 JF - Brain research JO - Brain Res VL - 643 IS - 1-2 N2 - On postnatal day 4 (PN4) Wistar rat pups were anesthetized and received bilateral infusions of 6-OHDA into the locus coeruleus or received vehicle infusions. On PN6 pups were trained in a classical conditioning paradigm with intra-oral milk infusions as the UCS and citral odor as the CS. Pups were trained in either 'paired', 'odor-only', 'milk-only' or 'backward' (milk then odor) conditions. On PN7 acquisition of a learned odor preference to the CS was tested in a two-odor choice test. HPLC analysis showed that locus coeruleus lesions significantly reduced olfactory bulb NE content but had no effect on olfactory bulb DA or 5-HT levels compared to controls. Pups receiving locus coeruleus lesions did not differ in behavioral response patterns during training compared to their littermate, vehicle controls. However, locus coeruleus lesions impaired acquisition of conditioned odor preferences. These results suggest that NE output from the locus coeruleus is critical for early olfactory learning. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/8032925/Bilateral_6_OHDA_lesions_of_the_locus_coeruleus_impair_associative_olfactory_learning_in_newborn_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-8993(94)90038-8 DB - PRIME DP - Unbound Medicine ER -