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Effect of surfactant mixtures on irritant contact dermatitis potential in man: sodium lauroyl glutamate and sodium lauryl sulphate.
Contact Dermatitis. 1994 Apr; 30(4):205-9.CD

Abstract

Our purpose was to ascertain the irritant contact dermatitis potential of sodium lauroyl glutamate (SLG) and to assess its possible anti-irritating potential in a surfactant mixture on human skin, using visual scores and measurement of transepidermal water loss (TEWL). 15 healthy adult volunteers free of skin disease and with no history of atopic dermatitis were treated with sodium lauryl sulphate (SLS) solution (1%, 0.75%, 0.50%, 0.25%), 1% SLG solution, and 1% surfactant mixture solutions, M1 (75/25), M2 (50/50), M3 (25/50) (SLG/SLS). We applied 100 microliters of solution using a polypropylene chamber for 24 h. Application sites for each solution were randomized to minimize anatomical bias. We measured baseline TEWL before test solution application. After removal of the patches, each site was visually graded and TEWL recorded with an evaporimeter daily for 4 days. The visual scores and TEWL values of 1% SLG solutions were lower than those of the other test solutions, except the vehicle control (deionized water). 1% surfactant mixture solutions showed lower visual scores and TEWL values than 1% SLS solution. Increase of SLG concentration decreased the visual scores and TEWL values. Comparing the visual scores and TEWL values of M1 and 0.25% SLS solution, M2 and 0.50% SLS solution, and M3 and 0.75% SLS solution, M1, M2, and M3 showed lower values, although not statistically different. These findings suggest that SLG is a mild surfactant and its utilization can decrease irritation potential in SLS and possibly other mixtures. This model may offer a facile system for screening the surfactant and other mixtures for decreased irritancy potential.

Authors+Show Affiliations

Department of Dermatology, School of Medicine, University of California San Francisco.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8033544

Citation

Lee, C H., et al. "Effect of Surfactant Mixtures On Irritant Contact Dermatitis Potential in Man: Sodium Lauroyl Glutamate and Sodium Lauryl Sulphate." Contact Dermatitis, vol. 30, no. 4, 1994, pp. 205-9.
Lee CH, Kawasaki Y, Maibach HI. Effect of surfactant mixtures on irritant contact dermatitis potential in man: sodium lauroyl glutamate and sodium lauryl sulphate. Contact Dermatitis. 1994;30(4):205-9.
Lee, C. H., Kawasaki, Y., & Maibach, H. I. (1994). Effect of surfactant mixtures on irritant contact dermatitis potential in man: sodium lauroyl glutamate and sodium lauryl sulphate. Contact Dermatitis, 30(4), 205-9.
Lee CH, Kawasaki Y, Maibach HI. Effect of Surfactant Mixtures On Irritant Contact Dermatitis Potential in Man: Sodium Lauroyl Glutamate and Sodium Lauryl Sulphate. Contact Dermatitis. 1994;30(4):205-9. PubMed PMID: 8033544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of surfactant mixtures on irritant contact dermatitis potential in man: sodium lauroyl glutamate and sodium lauryl sulphate. AU - Lee,C H, AU - Kawasaki,Y, AU - Maibach,H I, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 205 EP - 9 JF - Contact dermatitis JO - Contact Dermatitis VL - 30 IS - 4 N2 - Our purpose was to ascertain the irritant contact dermatitis potential of sodium lauroyl glutamate (SLG) and to assess its possible anti-irritating potential in a surfactant mixture on human skin, using visual scores and measurement of transepidermal water loss (TEWL). 15 healthy adult volunteers free of skin disease and with no history of atopic dermatitis were treated with sodium lauryl sulphate (SLS) solution (1%, 0.75%, 0.50%, 0.25%), 1% SLG solution, and 1% surfactant mixture solutions, M1 (75/25), M2 (50/50), M3 (25/50) (SLG/SLS). We applied 100 microliters of solution using a polypropylene chamber for 24 h. Application sites for each solution were randomized to minimize anatomical bias. We measured baseline TEWL before test solution application. After removal of the patches, each site was visually graded and TEWL recorded with an evaporimeter daily for 4 days. The visual scores and TEWL values of 1% SLG solutions were lower than those of the other test solutions, except the vehicle control (deionized water). 1% surfactant mixture solutions showed lower visual scores and TEWL values than 1% SLS solution. Increase of SLG concentration decreased the visual scores and TEWL values. Comparing the visual scores and TEWL values of M1 and 0.25% SLS solution, M2 and 0.50% SLS solution, and M3 and 0.75% SLS solution, M1, M2, and M3 showed lower values, although not statistically different. These findings suggest that SLG is a mild surfactant and its utilization can decrease irritation potential in SLS and possibly other mixtures. This model may offer a facile system for screening the surfactant and other mixtures for decreased irritancy potential. SN - 0105-1873 UR - https://www.unboundmedicine.com/medline/citation/8033544/Effect_of_surfactant_mixtures_on_irritant_contact_dermatitis_potential_in_man:_sodium_lauroyl_glutamate_and_sodium_lauryl_sulphate_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-1873&date=1994&volume=30&issue=4&spage=205 DB - PRIME DP - Unbound Medicine ER -