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Worldwide measles prevention.
Isr J Med Sci. 1994 May-Jun; 30(5-6):469-81.IJ

Abstract

Prior to measles vaccine use, measles accounted for over 2.5 million deaths annually. Measles epidemiology in the developed countries is different from that in less developed countries. Whereas in the developing world, measles is a disease primarily of young children, particularly infants in urban areas, in the developed world, school-age children > 5 years old play a greater role. Prevention of measles in developing countries has relied principally on a single dose of Schwarz strain vaccine at age 9 months (> 85% efficacy); 80% coverage has prevented > 1.6 million deaths. However, problems have been encountered because of the narrow window to deliver vaccines between the time an infant becomes susceptible and exposure to disease. Recent studies suggest that some strains of measles vaccines given at potencies 10-100 times higher than standard vaccines may achieve good efficacy in infants aged 4-6 months, but safety of these vaccines has been questioned. Widespread use of standard vaccines in the West has resulted in dramatic reductions in measles incidence but has not prevented outbreaks among the 2-5% of persons not protected by a single dose. Such outbreaks often appear after extended periods either without measles or with low measles incidence. A single dose appears adequate to control measles well but inadequate to eliminate the disease. Many developed countries have adopted two-dose schedules. Measles immunization has dramatically reduced measles occurrence, but improved control is necessary to prevent the estimated 1 million deaths still occurring each year.

Authors+Show Affiliations

Division of Immunization, Centers for Disease Control and Prevention, Atlanta, GA 30333.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8034506

Citation

Orenstein, W A., et al. "Worldwide Measles Prevention." Israel Journal of Medical Sciences, vol. 30, no. 5-6, 1994, pp. 469-81.
Orenstein WA, Markowitz LE, Atkinson WL, et al. Worldwide measles prevention. Isr J Med Sci. 1994;30(5-6):469-81.
Orenstein, W. A., Markowitz, L. E., Atkinson, W. L., & Hinman, A. R. (1994). Worldwide measles prevention. Israel Journal of Medical Sciences, 30(5-6), 469-81.
Orenstein WA, et al. Worldwide Measles Prevention. Isr J Med Sci. 1994 May-Jun;30(5-6):469-81. PubMed PMID: 8034506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Worldwide measles prevention. AU - Orenstein,W A, AU - Markowitz,L E, AU - Atkinson,W L, AU - Hinman,A R, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 469 EP - 81 JF - Israel journal of medical sciences JO - Isr J Med Sci VL - 30 IS - 5-6 N2 - Prior to measles vaccine use, measles accounted for over 2.5 million deaths annually. Measles epidemiology in the developed countries is different from that in less developed countries. Whereas in the developing world, measles is a disease primarily of young children, particularly infants in urban areas, in the developed world, school-age children > 5 years old play a greater role. Prevention of measles in developing countries has relied principally on a single dose of Schwarz strain vaccine at age 9 months (> 85% efficacy); 80% coverage has prevented > 1.6 million deaths. However, problems have been encountered because of the narrow window to deliver vaccines between the time an infant becomes susceptible and exposure to disease. Recent studies suggest that some strains of measles vaccines given at potencies 10-100 times higher than standard vaccines may achieve good efficacy in infants aged 4-6 months, but safety of these vaccines has been questioned. Widespread use of standard vaccines in the West has resulted in dramatic reductions in measles incidence but has not prevented outbreaks among the 2-5% of persons not protected by a single dose. Such outbreaks often appear after extended periods either without measles or with low measles incidence. A single dose appears adequate to control measles well but inadequate to eliminate the disease. Many developed countries have adopted two-dose schedules. Measles immunization has dramatically reduced measles occurrence, but improved control is necessary to prevent the estimated 1 million deaths still occurring each year. SN - 0021-2180 UR - https://www.unboundmedicine.com/medline/citation/8034506/Worldwide_measles_prevention_ L2 - http://www.diseaseinfosearch.org/result/4535 DB - PRIME DP - Unbound Medicine ER -